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New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

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dc.contributor.authorMoon, Kyuho-
dc.contributor.authorAhn, Chan-Hong-
dc.contributor.authorShin, Yoonho-
dc.contributor.authorWon, Tae Hyung-
dc.contributor.authorKo, Keebeom-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorOh, Ki-Bong-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorNam, Seung-Il-
dc.contributor.authorOh, Dong-Chan-
dc.coverage.spatialEast Siberian continental margin-
dc.coverage.spatialArctic-
dc.date.accessioned2017-08-03T12:51:50Z-
dc.date.available2017-08-03T12:51:50Z-
dc.date.issued2014-
dc.description.abstractTwo new secondary metabolites, arcticoside (1) and C-1027 chromophore-V (2), were isolated along with C-1027 chromophore-III and fijiolides A and B (3-5) from a culture of an Arctic marine actinomycete <em>Streptomyces</em> strain. The chemical structures of 1-2 were elucidated through NMR, mass, UV, and IR spectroscopy. The hexose moieties in 1 were determined to be D-glucose from a combination of acid hydrolysis, derivatization, and gas chromatographic analyses. Arcticoside (1) and C-1027 chromophore-V (2), which have a benzoxazine ring, inhibited <em>Candida albicans </em>isocitrate lyase. Chromophore-V (2) exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma cells (line HCT-116), with IC<sub>50</sub> values of 0.9 and 2.7 μM, respectively.-
dc.languageEnglish-
dc.subjectPharmacology & Pharmacy-
dc.subject.classificationAraon-
dc.titleNew Benzoxazine Secondary Metabolites from an Arctic Actinomycete-
dc.typeArticle-
dc.identifier.bibliographicCitationMoon, Kyuho, et al. 2014. "New Benzoxazine Secondary Metabolites from an Arctic Actinomycete". <em>Marine drugs</em>, 12(5): 2526-2538.-
dc.citation.titleMarine drugs-
dc.citation.volume12-
dc.citation.number5-
dc.citation.page2526-2538.-
dc.identifier.doi10.3390/MD12052526-
dc.coverage.x75°22.2743′N-
dc.coverage.y177°17.4846′E-
dc.subject.keywordArctic-
dc.subject.keywordMarine actinomycete-
dc.subject.keywordSecondary metabolite-
dc.subject.keywordAraon-
dc.coverage.degreeX75.3712383333333-
dc.coverage.degreeY177.29141-
Appears in Collections  
2014-2016, Reconstruction of Late Quaternary Glacial History and Paleoceanographic Changes in The Western Arctic (14-16) / Nam; Seung-Il
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