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A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7

Cited 1 time in scopus
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Title
A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7
Authors
Lee, Dong-Sung
Cui, Xiang
Ko, Wonmin
Kim, Kyoung-Su
Kim, Il-Chan
Yim, Joung Han
An, Ren-Bo
Kim, Youn-Chul
Oh, Hyuncheol
Subject
Pharmacology & Pharmacy
Keywords
Sea urchin; New sulfonic acid derivative; (Z)-4-Methylundeca-1,9-diene-6-sulfonic acid; Anti-inflammation; Nuclear factor-κB; Mitogen-activated protein kinase
Issue Date
2014
Citation
Lee, Dong-Sung., et al. 2014. A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7. Archives of Pharmacal Research, 37: 983-991.
Abstract
In this study, we isolated a new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid (1), from the sea urchin collected from the Sea of Okhotsk. We established the structure of this new compound by analysis of NMR and HRMS data, along with comparison of the data with those of the related compounds reported in the literature. In addition, we investigated its anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages. Compound 1 inhibited the production of NO, iNOS, PGE2, and COX-2, and it also suppressed the production of proinflammatory cytokines, such as TNF-a and IL-1b. It inhibited the translocation of the NF-jB subunit p65 into the nucleus by interrupting the phosphorylation and degradation of IjB-a. In addition, compound 1 significantly decreased the phosphorylation of JNK and p38 in LPSstimulated RAW264.7 macrophages, suggesting that suppression of the inflammation process by compound 1 was mediated through the MAPK pathway. Taken together, this study showed that the anti-inflammatory effects of a new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6- sulfonic acid were mediated through the inhibition of NFjB and JNK/p38 MAPK signaling pathways.
DOI
10.1007/s12272-013-0269-1
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