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Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum

Cited 16 time in wos
Cited 16 time in scopus

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dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorSripisut, Tawanun-
dc.contributor.authorPark, Eun-Jung-
dc.contributor.authorKondratyuk, Tamara P.-
dc.contributor.authorFatima, Nighat-
dc.contributor.authorSimmons, Charles J.-
dc.contributor.authorWall, Marisa M.-
dc.contributor.authorSun, Dianqing-
dc.contributor.authorPezzuto, John M.-
dc.contributor.authorChang, Leng Chee-
dc.date.accessioned2017-08-03T12:52:51Z-
dc.date.available2017-08-03T12:52:51Z-
dc.date.issued2015-
dc.description.abstractChemical investigation of an endophytic fungus <em>Chaetomium globosum</em> isolated from leaves of <em>Wikstroemia uva-ursi</em> led to the isolation of two new azaphilones, chaetoviridins J and K (1 and 3), along with five known derivatives (2 and 4-7). The structures of azaphilones were determined by NMR, X-ray diffraction, Mosher's method, and CD analysis. The isolated compounds were evaluated for their cancer chemopreventive-potential based on their abilities to inhibit tumor necrosis factor alpha (TNF-a)-induced nuclear factor-kappa B (NF-jB). Compounds 4, 5, 7, and synthetic 8 and 9 inhibit nitric oxide (NO) production with IC50 values in the range of 0.3-5.8 lM. Compounds 4, 5, and 9 also displayed (TNF-a)-induced NF-jB activity with IC50 values in the range of 0.9-5.1 lM.-
dc.languageEnglish-
dc.subjectPharmacology & Pharmacy-
dc.subjectChemistry-
dc.titleDetermination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum-
dc.typeArticle-
dc.identifier.bibliographicCitationYoun, Ui Joung, et al. 2015. "Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum". <em>Bioorganic & Medicinal Chemistry Letters</em>, 25: 4719-4723.-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume25-
dc.citation.page4719-4723-
dc.identifier.doi10.1016/j.bmcl.2015.08.063-
dc.subject.keywordChaetomium globosum-
dc.subject.keywordWikstroemia uva-ursi-
dc.subject.keywordAzaphilone-
dc.subject.keywordX-ray crystallography-
dc.subject.keywordAnti-inflammatory activity-
dc.identifier.scopusid2-s2.0-84944177892-
dc.identifier.wosid000363275400004-
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
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