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Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis

Cited 2 time in scopus
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Title
Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis
Authors
Youn, Ui Joung
Park, Eun-Jung
Kondratyuk, Tamara P.
Sripisut, Tawanun
Laphookhieo, Surat
Pezzuto, John M.
Chang, Leng Chee
Subject
Pharmacology & Pharmacy
Keywords
Gardenia sootepenesis; Rubiaceae; Cycloartane triterpenes; Anti-inflammatory activity
Issue Date
2016
Citation
Youn, Ui Joung, et al. 2016. "Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis". Fitoterapia, 114: 92-97.
Abstract
Bioassay-guided fractionation of the dichloromethane extract fromthe apical bud of Gardenia sootepenesis Hutch. (Rubiaceae) led to the isolation of four new cycloartane triterpenes, sootepins F?I (1?4), along with four known derivatives (5?8). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison of the physicochemical datawith published values. The isolates were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α)-induced nuclear factor kappa (NF-κB) activity. Compounds 6?8 inhibited TNF-α-induced NF-κB activity with half maximal inhibitory concentration (IC50) values of 8.3, 5.6, and 6.0 μM, respectively; compounds 7 and 8 showed significant NO-inhibitory activity with IC50 values of 3.2 and 2.0 μM, respectively.
DOI
http://dx.doi.org/10.1016/j.fitote.2016.08.012
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