Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis
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- Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis
- Youn, Ui Joung
Kondratyuk, Tamara P.
Pezzuto, John M.
Chang, Leng Chee
- Pharmacology & Pharmacy
- Gardenia sootepenesis; Rubiaceae; Cycloartane triterpenes; Anti-inflammatory activity
- Issue Date
- Youn, Ui Joung, et al. 2016. "Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis". Fitoterapia, 114: 92-97.
- Bioassay-guided fractionation of the dichloromethane extract fromthe apical bud of Gardenia sootepenesis Hutch.
(Rubiaceae) led to the isolation of four new cycloartane triterpenes, sootepins F？I (1？4), along with four known
derivatives (5？8). The structures of the new compounds were determined by 1D and 2D NMR experiments and
by comparison of the physicochemical datawith published values. The isolates were evaluated for cancer chemopreventive
potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor-alpha
(TNF-α)-induced nuclear factor kappa (NF-κB) activity. Compounds 6？8 inhibited TNF-α-induced NF-κB activity
with half maximal inhibitory concentration (IC50) values of 8.3, 5.6, and 6.0 μM, respectively; compounds 7 and 8
showed significant NO-inhibitory activity with IC50 values of 3.2 and 2.0 μM, respectively.
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