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Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates

Cited 8 time in scopus
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Title
Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates
Authors
Youn, Ui Joung
Park, Eun-Jung
Kondratyuk, Tamara P.
Sang-Ngern, Mayuramas
Wall, Marisa M.
Wei, Yanzhang
Pezzuto, John M.
Chang, Leng Chee
Subject
Plant Sciences; Pharmacology & Pharmacy
Issue Date
2016
Citation
Youn, Ui Joung, et al. 2016. "Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates". Journal of Natural Products, 79: 1508-1513.
Abstract
A new fatty acid ester disaccharide, 2-O-(β-Dglucopyranosyl)- 1-O-(2E,4Z,7Z)-deca-2,4,7-trienoyl-β-D-glucopyranose (1), a new ascorbic acid derivative, 2-caffeoyl-3- ketohexulofuranosonic acid γ-lactone (2), and a new iridoid glycoside, 10-dimethoxyfermiloside (3), were isolated along with 13 known compounds (4?16) from fermented noni fruit juice (Morinda citrifolia). The structures of the new compounds, together with 4 and 5, were determined by 1D and 2D NMR experiments, as well as comparison with published values. Compounds 2 and 7 showed moderate inhibitory activities in a TNF-α-induced NF-κB assay, and compounds 4 and 6 exhibited considerable quinone reductase-1 (QR1) inducing effects.
DOI
http://dx.doi.org/10.1021/acs.jnatprod.5b00970
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