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Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia

Cited 25 time in wos
Cited 26 time in scopus

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dc.contributor.authorKim, Dong-Cheol-
dc.contributor.authorQuang, Tran Hong-
dc.contributor.authorNgan, Nguyen Thi Thanh-
dc.contributor.authorYoon, Chi-Su-
dc.contributor.authorSohn, Jae Hak-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorFeng, Yu-
dc.contributor.authorChe, Yongsheng-
dc.contributor.authorKim, Youn-Chul-
dc.contributor.authorOh, Hyuncheol-
dc.date.accessioned2017-08-03T12:52:59Z-
dc.date.available2017-08-03T12:52:59Z-
dc.date.issued2016-
dc.description.abstractChemical investigation of the EtOAc extracts of marine-derived fungal isolates <em>Aspergillus</em> sp. SF-5974 and Aspergillus sp. SF-5976 yielded a new dihydroisocoumarin derivative (1) and 12 known metabolites. The structures of the isolated metabolites were established by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Among the metabolites, the absolute configuration of 5′-hydroxyasperentin (6) was determined by single-crystal X-ray diffraction analysis. The in vitro antineuroinflammatory effects of the metabolites were also evaluated in lipopolysaccharide (LPS)- stimulated microglial cells. Among the isolated metabolites, dihydroisocoumarin derivatives 1?6 (10?80 μM) were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated BV2 microglia. Further, 1 (20?80 μM) was found to suppress the phosphorylation of the inhibitor of nuclear factor kappa B-α (IκB-α), interrupt the nuclear translocation of nuclear factor kappa B (NF-κB), and decrease the activation of p38 mitogen-activated protein kinase (MAPK).-
dc.languageEnglish-
dc.subjectPlant Sciences-
dc.subjectPharmacology & Pharmacy-
dc.titleDihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia-
dc.typeArticle-
dc.identifier.bibliographicCitationKim, Dong-Cheol, et al. 2016. "Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia". <em>Journal of Natural Products</em>, 79: 2948-2955.-
dc.citation.titleJournal of Natural Products-
dc.citation.volume79-
dc.citation.page2948-2955-
dc.identifier.doi10.1021/acs.jnatprod.5b00614-
dc.identifier.scopusid2-s2.0-84953239234-
dc.identifier.wosid000367562600010-
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
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