Chemical Constituents from the Aerial Parts of Vernonia cinerea L. and Their Anti-Inflammatory Activity
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- Chemical Constituents from the Aerial Parts of Vernonia cinerea L. and Their Anti-Inflammatory Activity
- Youn, Ui Joung
Chang, Leng Chee
- Vernonia cinerea L; Anti-Inflammatory activity; Asteraceae; Phenolic Compounds
- Issue Date
- Youn, Ui Joung and Leng Chee Chang. 2016. Chemical Constituents from the Aerial Parts of Vernonia cinerea L. and Their Anti-Inflammatory Activity. Korean Journal of Medicinal Crop Science, 24(6): 437-443.
- Background: Previous phytochemical studies of whole Vernonia cinerea L. plants have identified sesquiterpene lactones, sterols,
and triterpenes, which possess anticancer, antifeedant, and antimalarial activities. However, there are no reports of other types of
bioactive metabolites. Therefore, the present study aimed to identify phenolic compounds with anti-inflammatory activity in the
aerial parts of the plant.
Methods and Results: Compounds were isolated from the aerial parts of V. cinerea using a silica and C-18 gel columns and semipreparative
HPLC instrument, and the structures of the compounds were determined using one- and two- dimension nuclear magnetic
resonance spectroscopy and mass spectroscopy. The chloroform soluble extracts and isolated compounds were evaluated for
their anti-inflammatory potential based on their ability to inhibit nitric oxide production and TNF-α induced NF-κB activity.
Conclusions: Phytochemical study of the aerial parts of V. cinerea led to the isolation of six phenolic compounds. Compound 1 was
a major metabolite, and to the best of our knowledge, compounds 2 - 6 were isolated from V.cinerea for the first time. Among the
isolates, compounds 1 and 3 exhibited TNF-α-induced NF-κB activity with IC50 values of 7.5 and 11.5 M, respectively, and the
inhibitory activity of phenyl propanoid compound 3 on TNF-α-induced NF-κB was evaluated for the first time.
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