Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013
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- Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013
- Lee, Sook-Young
No, Jin Sun
- Science & Technology - Other Topics
- Adelie Penguin; Chinstrap penguin; Novel Adenovirus
- Issue Date
- Lee, Sook-Young., et al. 2015. Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013. PLoS ONE, 11(6): e0157032.
- Antarctica is considered a relatively uncontaminated region with regard to the infectious diseases because of its extreme environment, and isolated geography. For the genetic characterization and molecular epidemiology of the newly found penguin adenovirus in Antarctica, entire genome sequencing and annual survey of penguin adenovirus were conducted. The entire genome sequences of penguin adenoviruses were completed for two Chinstrap enguins (Pygoscelis antarctica) and two Gentoo penguins (Pygoscelis papua). The whole genome lengths and G+C content of penguin adenoviruses were found to be 24,630 - 24,662 bp and 35.5 - 35.6%, respectively. Notably, the presence of putative sialidase gene was not identified in penguin adenoviruses by Rapid Amplification of cDNA Ends (RACEPCR) as well as consensus specific PCR. The penguin adenoviruses were demonstrated to
be a new species within the genus Siadenovirus, with a distance of 29.9 - 39.3%(amino
acid, 32.1？47.9%) in DNA polymerase gene, and showed the closest relationship with turkey
adenovirus 3 (TAdV-3) in phylogenetic analysis. During the 2008？2013 study period,
the penguin adenoviruses were annually detected in 22 of 78 penguins (28.2%), and the
molecular epidemiological study of the penguin adenovirus indicates a predominant infection
in Chinstrap penguin population (12/30, 40%). Interestingly, the genome of penguin
adenovirus could be detected in several internal samples, except the lymph node and brain.
In conclusion, an analysis of the entire adenoviral genomes from Antarctic penguins was
conducted, and the penguin adenoviruses, containing unique genetic character, were identified
as a new species within the genus Siadenovirus. Moreover, it was annually detected in
Antarctic penguins, suggesting its circulation within the penguin population.
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