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Antibacterial potential of Antarctic Lichens against Human Pathogenic Gram Positive Bacteria

Cited 30 time in scopus
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Title
Antibacterial potential of Antarctic Lichens against Human Pathogenic Gram Positive Bacteria
Other Titles
인감감염 그람양성미생물에 대한 남극지의류의 항미생물 활성
Authors
Paudel, Babita
Hong, Soon Gyu
Yim, Joung Han
Shin, Hyun Woung
Lee, Jin Sung
Bhattarai, Hari Datta
Subject
Pharmacology & Pharmacy
Keywords
Antarctic lichens; Antibacterial activity; Gram(+) bacteria; Minimum inhibitory concentrati
Issue Date
2008
Publisher
Wiley Interscience
Citation
Paudel, Babita, et al. 2008. "Antibacterial potential of Antarctic Lichens against Human Pathogenic Gram Positive Bacteria". PHYTOTHERAPY RESEARCH, 22(9): 1269-1271.
Abstract
Extracts from five Antarctic lichens (L3, Stereocaulon alpinum;L5, Ramalina terebrata;L6, Caloplaca sp.;L8, Lecanora sp.;and L17, Caloplaca regalis) were tested for antimicrobial activities against several clinically important microbes by disk diffusion. The minimum inhibitory concentration (MIC) of each extract was determined by broth dilution method. Extracts from L3, L5, L6 and L8 were active against two Gram(+) strains. B. subtilis was more sensitive to lichen extracts (except L5) than S. aureus. The MIC of lichen extracts against B. subtilis and S. aureus was observed from 36.7 ?0.3 to 953.8?85.8 ?g ml-1 and 68.5?0.6 to >1000 ?g ml-1, respectively. Comparisons of MIC values of Antarctic lichen crude extracts to previously published MIC values of some reported lichen metabolites against Gram(+) bacteria indicated that Antarctic lichens might be an enriched source of effective antibacterial agents against clinically relevant Gram(+) species.
URI
http://repository.kopri.re.kr/handle/201206/6123
DOI
http://dx.doi.org/10.1002/ptr.2445
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