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Arabidopsis Histone Methyltransferase SET DOMAIN GROUP2 is Required for Regulation of Various Hormone Responsive Genes

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Title
Arabidopsis Histone Methyltransferase SET DOMAIN GROUP2 is Required for Regulation of Various Hormone Responsive Genes
Other Titles
애기장대 히스톤 메틸트랜스퍼레이즈 SDG2 단백질이 여러 호르몬 반응 유전자들을 조절하는 기작 (공동 제1저자)
Authors
Lee, Jungeun
Kim, Sanghee
Nam-Hai Chua
Choonkyun Jung
Jun-Yi Yang
Subject
Plant Sciences
Keywords
Arabidopsis thaliana; H3K4 tri-methylation; Histone modification; Plant hormone response
Issue Date
2013
Publisher
한국식물학회지
Citation
Lee, Jungeun, et al. 2013. "Arabidopsis Histone Methyltransferase SET DOMAIN GROUP2 is Required for Regulation of Various Hormone Responsive Genes". JOURNAL OF PLANT BIOLOGY, 56(1): 39-48.
Abstract
Histone modifications are known to play important roles in plant development through epigenetic regulation of gene expression. How these modifications regulate downstream targets under various environmental cues and developmental stimuli is still largely unknown. Here, we provide evidence that Arabidopsis histone H3K4 methyltransferase SET DOMAIN GROUP2 (SDG2) is required for full activation of hormone responsive genes upon hormone treatment. The pleiotropic phenotypes of sdg2 were closely related to those of auxin deficient mutants and RNA analysis revealed that expression of early hormone responsive genes was significantly reduced in sdg2-5. By ChIP analyses we found that H3K4 tri-methylations on chromatin region of hormone responsive genes such as SAUR27, KIN1 and GASA6 were enriched in WT upon hormone treatments whereas these enrichments were largely abolished in sdg2-5. After hormone treatment, chromatin regions of responsive genes that accumulated H3K4me3 in WT overlapped with those displaying decreased H3K4me3 levels in sdg2-5. Histone H3K4 di-methylation levels on tested genes were increased rather than decreased in sdg2-5, suggesting that SDG2 mediates transition of H3K4me2 to H3K4me3. Taken together, we conclude that the SDG2 activity is required to regulate the expression of hormone responsive genes via histone H3K4 tri-methylation.i is still largely unknown. Here, we provide evidence that Arabidopsis histone H3K4 methyltransferase SET DOMAIN GROUP2 (SDG2) is required for full activation of hormone responsive genes upon hormone treatment. The pleiotropic phenotypes of sdg2 were closely related to those of auxin deficient mutants and RNA analysis revealed that expression of early hormone responsive genes was significantly reduced in sdg2-5. By ChIP analyses we found that H3K4 tri-methylations on chromatin region of hormone responsive genes such as SAUR27, KIN1 and GASA6 were enriched in WT upon hormone treatments whe
URI
http://repository.kopri.re.kr/handle/201206/6203
DOI
http://dx.doi.org/10.1007/s12374-012-0320-7
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