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Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum

Cited 18 time in scopus
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Title
Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum
Other Titles
남극 이끼류 Polytrichastrum alpinum로부터 benzonaphthoxanthenone계 Ohioensins F와 G의 PTP1B 저해
Authors
Seo, Changon
Choi, Yun-Hyeok
Sohn, Jae Hak
Oh, Hyuncheol
Lee, Hong Kum
Yim, Joung Han
Subject
Plant Sciences
Keywords
Ohioensins F and G; Polytrichastrum alpinum; Protein tyrosine phosphatase 1
Issue Date
2008
Citation
Seo, Changon, et al. 2008. "Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(1): 772-775.
Abstract
Ohioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B). Kinetic analysis of PTP1B inhibition by ohioensin F(1) suggested that benzonaphthoxanthenones inhibited PTP1B activity in a non-competitive manner. (c) 2007 Elsevier Ltd. All rights reserved.
URI
http://repository.kopri.re.kr/handle/201206/6220
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.11.036
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