Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum
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- Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum
- Other Titles
- 남극 이끼류 Polytrichastrum alpinum로부터 benzonaphthoxanthenone계 Ohioensins F와 G의 PTP1B 저해
- Seo, Changon
Sohn, Jae Hak
Lee, Hong Kum
Yim, Joung Han
- Plant Sciences
- Ohioensins F and G; Polytrichastrum alpinum; Protein tyrosine phosphatase 1
- Issue Date
- Seo, Changon, et al. 2008. "Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(1): 772-775.
- Ohioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B). Kinetic analysis of PTP1B inhibition by ohioensin F(1) suggested that benzonaphthoxanthenones inhibited PTP1B activity in a non-competitive manner. (c) 2007 Elsevier Ltd. All rights reserved.
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