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New diterpene furanoids from the Antarctic lichen Huea sp

Cited 11 time in scopus
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Title
New diterpene furanoids from the Antarctic lichen Huea sp
Other Titles
남극지의류 Huer sp. 유래 신규 diterpene furanoids
Authors
Yinglan Cui
Dong-Sung Lee
Yim, Joung Han
Hyuncheol Oh
Youn-Chul Kim
Subject
Pharmacology & Pharmacy; Chemistry
Keywords
Diterpene furanoids; Huea sp; Non-competitive inhibitor; Protein tyrosine phosphatase 1
Issue Date
2012
Publisher
elsevier
Citation
Yinglan Cui, et al. 2012. "New diterpene furanoids from the Antarctic lichen Huea sp". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(24): 7393-7396.
Abstract
In the course of ongoing research on protein tyrosine phosphatase 1B (PTP1B) inhibitory compounds from Antarctic lichens, four new diterpene furanoids, hueafuranoids A? D (1? 4) have been isolated from the MeOH extract of Antarctic lichen Huea sp. by various chromatographic methods. The structures of these compounds were elucidated by analysis of NMR and MS data, and comparing their spectral data with those in the literature. Compound 1 showed inhibitory activity against therapeutically targeted protein, PTP1B with an IC50 value of 13.9 lM. The kinetic analysis of PTP1B inhibition by hueafuranoid A (1) suggested that the diterpene furanoids encountered in this study inhibited PTP1B activity in a non- competitive manner.tarctic lichen Huea sp. by various chromatographic methods. The structures of these compounds were elucidated by analysis of NMR and MS data, and comparing their spectral data with those in the literature. Compound 1 showed inhibitory activity against therapeutically targeted protein, PTP1B with an IC50 value of 13.9 lM. The kinetic analysis of PTP1B inhibition by hueafuranoid A (1) suggested that the diterpene furanoids encountered in this study inhibited PTP1B activity in a non- competitive manner.
URI
http://repository.kopri.re.kr/handle/201206/6222
DOI
http://dx.doi.org/10.1016/j.bmcl.2012.10.063
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