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Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells

Cited 12 time in scopus
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Title
Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells
Other Titles
평활근을 이용한 스테레오칼핀 a의 부착물질 저해효과
Authors
Dong-Kwon Rhee
Yim, Joung Han
Suhkneung Pyo
Eun-Yi Moon
Lee, Hong Kum
Bong-Kyun Park
Hye-Eun Byeon
Subject
Immunology; Pharmacology & Pharmacy
Keywords
Cell adhesion molecule; Inflammation; MAPK; ROS; Stereocalpin A
Issue Date
2012
Publisher
elsevier
Citation
Dong-Kwon Rhee, et al. 2012. "Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells". INTERNATIONAL IMMUNOPHARMACOLOGY, 12: 315-325.
Abstract
Up-regulation of cell adhesionmolecules on vascular smoothmuscle cells (VSMCs) and leukocyte recruitment to the vascularwall contribute to vascular inflammation and atherosclerosis. Stereocalpin A, a chemical compound of the Antarctic lichen Ramalina terebarata, displays tumoricidal activity against several different tumor cell types. However, other biological activities of stereocalpin A and its molecular mechanisms remain unknown. In this study, ourwork is directed toward studying the in vitro effects of stereocalpin A on the ability to suppress the expression of adhesion molecules induced by TNF-α in vascular smooth muscle cells. Pretreatment of VSMCs for 2 h with stereocalpin A at nontoxic concentrations of 0.1?10 μg/ml inhibited TNF-α- induced adhesion of THP-1monocytic cells and expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Stereocalpin A reduced TNF-α-induced production of intracellular reactive oxygen species (ROS) and phosphorylation of p38, ERK, JNK and Akt. Stereocalpin A also inhibited NK-κB activation induced by TNF-α.Moreover, stereocalpin A inhibited TNF-α-induced ΙκΒ kinase activation, subsequent degradation of ΙκΒα, and nuclear translocation of NF-κ B. Hence, we describe a new anti-inflammatory activity and mechanism of stereocalpin A, owing to the negative regulation of TNF-α-induced adhesion ichen Ramalina terebarata, displays tumoricidal activity against several different tumor cell types. However, other biological activities of stereocalpin A and its molecular mechanisms remain unknown. In this study, ourwork is directed toward studying the in vitro effects of stereocalpin A on the ability to suppress the expression of adhesion molecules induced by TNF-α in vascular smooth muscle cells. Pretreatment of VSMCs for 2 h with stereocalpin A at nontoxic concentrations of 0.1?10 μg/ml inhibited TNF-α- induced adhesion of THP-1
URI
http://repository.kopri.re.kr/handle/201206/6271
DOI
http://dx.doi.org/10.1016/j.intimp.2011.11.020
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