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A new fused tetracyclic heterocyclic antioxidant from Serratia sp. PAMC 25557

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Title
A new fused tetracyclic heterocyclic antioxidant from Serratia sp. PAMC 25557
Other Titles
극지 미생물 Serratia sp. 유래 compound의 항산화 효과
Authors
Hari
Kim, Il-Chan
Babita
Yim, Joung Han
Oh, Hyuncheol
Subject
Plant Sciences; Pharmacology & Pharmacy
Keywords
Antioxidant; DPPH free radical; Serratia
Issue Date
2013
Publisher
Elsevier
Citation
Hari, et al. 2013. "A new fused tetracyclic heterocyclic antioxidant from Serratia sp. PAMC 25557". phytochemistry letters, 6(4): 536-538.
Abstract
A new fused tetracyclic heterocyclic compound, (4bR,10bR)-4b-hydroxy-10b,12-dihydrodiben- zo[c,h][2,6]naphthyridine-5,11(4bH,6H)-dione (1), and a known compound, butyl 2-[(benzoyloxy)- methyl]benzoate, spatozoate 2, were isolated from the broth culture of Serratia sp. PAMC 25557. The structure of 1 was determined by analyzing spectroscopic data. Compound 1 did not exhibit antimicrobial activity against Escherichia coli, Staphylococcus aureus, or Candida albicans. In addition, up to 100 mg/ml compound 1 did not show any toxicity against Artemia salina larvae. However, compound 1 showed DPPH free radical scavenging activity (IC50 = 16.7 0.34 mg/ml). This was the first report of spatozoate isolation from bacterial sources. broth culture of Serratia sp. PAMC 25557. The structure of 1 was determined by analyzing spectroscopic data. Compound 1 did not exhibit antimicrobial activity against Escherichia coli, Staphylococcus aureus, or Candida albicans. In addition, up to 100 mg/ml compound 1 did not show any toxicity against Artemia salina larvae. However, compound 1 showed DPPH free radical scavenging activity (IC50 = 16.7 0.34 mg/ml). This was the first report of spatozoate isolation from bacterial sources.
URI
http://repository.kopri.re.kr/handle/201206/6296
DOI
http://dx.doi.org/10.1016/j.phytol.2013.07.006
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