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Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum

Cited 25 time in scopus
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Title
Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum
Other Titles
남극 지의류 유래 bioactive cyclic depsipeptide인 Stereocalpin A
Authors
Lee, Hong Kum
Park, Seong Min
Oh, Hyuncheol
Yim, Joung Han
Seo, Changon
Sohn, Jae Hak
Subject
Immunology; Marine & Freshwater Biology; Veterinary Sciences
Keywords
Cyclic depsipeptid; Stereocalpin A; Stereocaulon alpinum; Fisheries
Issue Date
2008
Citation
Lee, Hong Kum, et al. 2008. "Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum". TETRAHEDRON LETTERS, 18(0): 772-775.
Abstract
A new cyclic depsipeptide stereocalpin A (1) has been isolated from the MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structure of stereocalpin A (1) was mainly determined by analysis of the NMR spectroscopic data and by chemical methods. Stereocalpin A (1) is a unique cyclic peptide incorporating an unprecedented 5-hydroxy-2,4-dimethyl-3-oxo-octanoic acid in the structure. Stereocalpin A (1) shows moderate cytotoxicity against three human solid tumor cell lines. (C) 2007 Elsevier Ltd. All rights reserved.
URI
http://repository.kopri.re.kr/handle/201206/6317
DOI
http://dx.doi.org/10.1016/j.tetlet.2007.11.022
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