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Usimines A-C, Bioactive Usnic Acid Derivatives from the Antarctic Lichen Stereocaulon alpinum

Cited 21 time in scopus
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Title
Usimines A-C, Bioactive Usnic Acid Derivatives from the Antarctic Lichen Stereocaulon alpinum
Other Titles
남극 지의류 Stereocaulon alpinum으로부터 생물활성을 가지는 Usnic Acid 유도체
Authors
Lee, Hong Kum
Oh, Hyuncheol
Yim, Joung Han
Seo, Changon
Sohn, Jae Hak
Subject
Plant Sciences; Pharmacology & Pharmacy
Keywords
Antarctic Lichen; Stereocaulon alpinum; Usnic Acid Derivatives
Issue Date
2008
Publisher
American Chemical Society and American Society of Pharmacognosy
Citation
Lee, Hong Kum, et al. 2008. "Usimines A-C, Bioactive Usnic Acid Derivatives from the Antarctic Lichen Stereocaulon alpinum". JOURNAL OF NATURAL PRODUCTS, 71(1): 710-712.
Abstract
Usimines A-C (1?3), three new usnic acid derivatives, have been isolated from a MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of 1?3 were determined by analysis of their spectroscopic data (NMR, UV, MS) and by chemical methods. The known compound usnic acid (4) was also obtained. Compounds 1?4 showed moderate inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B).
URI
http://repository.kopri.re.kr/handle/201206/6335
DOI
http://dx.doi.org/10.1021/np070464b
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