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PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica

Cited 16 time in wos
Cited 19 time in scopus

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dc.contributor.authorChangon Seo-
dc.contributor.authorHyuncheol Oh-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorLee, Hong Kum-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorYun-Hyeok Choi-
dc.date.accessioned2018-03-20T13:52:13Z-
dc.date.available2018-03-20T13:52:13Z-
dc.date.issued2009-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/6369-
dc.description.abstractThe selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried sample of the Antarctic lichen Umbilicaria antarctica was found to exhibit significant inhibitory effect, and the bioassay-guided fractionation and purification afforded three related lichen metabolites 1-3. Compounds 1-3 were identified as gyrophoric acid (1), lecanoric acid (2), and methyl orsellinate (3) mainly by analysis of NMR and MS data. These compounds inhibited PTP1B activity with 50% inhibitory concentration values of 3.6 ± 0.04 μM, 31 ± 2.7 μM, and 277 ± 8.6 μM, respectively. Furthermore, the kinetic analysis of PTP1B inhibition by compound 1 suggested that the compound inhibited PTP1B activity in a non-competitive manner.-
dc.languageEnglish-
dc.publisherInforma helthcare-
dc.subjectBiochemistry & Molecular Biology-
dc.subjectPharmacology & Pharmacy-
dc.titlePTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica-
dc.title.alternative남극지의류 Umbilicaria antarctica로 부터 분리한 tridepside의 PTP1B 저해효과-
dc.typeArticle-
dc.identifier.bibliographicCitationChangon Seo, et al. 2009. "PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica". <em>JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY</em>, 24(5): 1133-1137.-
dc.citation.titleJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY-
dc.citation.volume24-
dc.citation.number5-
dc.identifier.doi10.1080/14756360802667811-
dc.citation.startPage1133-
dc.citation.endPage1137-
dc.description.articleClassificationSCI-
dc.description.jcrRateJCR 2007:80.22813688212928-
dc.subject.keywordAntarctic lichen-
dc.subject.keywordLichen metabolites-
dc.subject.keywordNon-competitive inhibitor-
dc.subject.keywordProtein tyrosine phosphatase 1-
dc.subject.keywordUmbilicaria antarctica-
dc.identifier.localId2009-0112-
dc.identifier.scopusid2-s2.0-74549186582-
dc.identifier.wosid000271613300013-
Appears in Collections  
2006-2010, Procurement and utilization of polar genetic resources (06-10) / Lee, Hong Kum; Yim, Joung Han (PE06050, PE07050, PE08050, PE09050, PE10050)
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