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Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes

Cited 29 time in scopus
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Title
Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes
Other Titles
Single-Molecule Real-Time Sequencing 기법을 이용한 high-gc content 게몬분석
Authors
Shin, Seung Chul
Park, Hyun
Lee, Jong Eun
Oh, Tae-Jin
Lee, Hyoungseok
Kim, Su Jin
Ahn, Do Hwan
Subject
Science & Technology - Other Topics
Issue Date
2013
Publisher
Public
Citation
Shin, Seung Chul, et al. 2013. "Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes". PLOS ONE, 8: e68824-e68824.
Abstract
Next-generation sequencing has become the most widely used sequencing technology in genomics research, but it has inherent drawbacks when dealing with high-GC content genomes. Recently, single-molecule real-time sequencing technology (SMRT) was introduced as a third-generation sequencing strategy to compensate for this drawback. Here, we report that the unbiased and longer read length of SMRT sequencing markedly improved genome assembly with high GC content via gap filling and repeat resolutionT) was introduced as a third-generation sequencing strategy to compensate for this drawback. Here, we report that the unbiased and longer read length of SMRT sequencing markedly improved genome assembly with high GC content via gap filling and repeat resolution
URI
http://repository.kopri.re.kr/handle/201206/6463
DOI
http://dx.doi.org/10.1371/journal.pone.0068824
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