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Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells

Cited 2 time in scopus
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Title
Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells
Other Titles
유사 마이코스포린 아미노산의 일종인 porphyra-334가 HaCaT세포에서 자외선에의해 야기되는 세포사멸 완화
Authors
Suh, Sung-Suk
Kim, Sanghee
Kim, Il-Chan
Lee, Sung Gu
Oh, Se Kyung
Subject
Pharmacology & Pharmacy
Keywords
HaCaT cells; UV irradiation; apoptosis; cell proliferation; porphyra-334
Issue Date
2017
Citation
Suh, Sung-Suk, et al. 2017. "Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells". ACTA PHARMACEUTICA, 67: 257-264.
Abstract
The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs) which are well known as UV-absorbing compounds, on UV-induced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have attracted considerable attention recently in both industry and research in pharmacology. Here, human HaCaT cells were used to determine the biological activities of porphyra-334 by various in vitro assays including proliferation, apoptosis, and Western blot assays. The proliferation rate of UV-irradiated HaCaT cells was significantly decreased compared with the control group. Pretreatment with porphyra-334 markedly attenuated the inhibitory effect of UV and induced a dramatic decrease in the apoptotic rate. Expression of active caspase-3 protein was increased in response to UV irradiation, while caspase-3 levels were similar between cells treated with porphyra-334 and the non-irradiated control group. Taken together, our data suggest that porphyra-334 inhibits UV-induced apoptosis in HaCaT cells through attenuation of the caspase pathway
URI
http://repository.kopri.re.kr/handle/201206/6485
DOI
http://dx.doi.org/10.1515/acph-2017-0015
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