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Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant

Cited 10 time in scopus
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Title
Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant
Other Titles
해양 결빙방지단백질의 구조, 기능 그리고 동결보존제로써의 활용
Authors
Hak Jun Kim
Bon-Won Koo
Park, Sun-Ha
Lee, Chang Woo
Young Baek Hur
Lee, Jun Hyuck
Subject
Pharmacology & Pharmacy
Keywords
antifreeze proteins; cryoprotectant; ice recrystallization inhibition; ice-binding proteins; slow-freezing; vitrification
Issue Date
2017
Citation
Hak Jun Kim, et al. 2017. "Marine Antifreeze Proteins: Structure, Function, and Application to Cryopreservation as a Potential Cryoprotectant". MARINE DRUGS, 15: 1-27.
Abstract
Antifreeze proteins (AFPs) are biological antifreezes with unique properties, including thermal hysteresis (TH), ice recrystallization inhibition (IRI), and interaction with membranes and/or membrane proteins. These properties have been utilized in the preservation of biological samples at low temperatures. Here, we review the structure and function of marine-derived AFPs, including moderately active fish AFPs and hyperactive polar AFPs. We also survey previous and current reports of cryopreservation using AFPs. Cryopreserved biological samples are relatively diverse ranging from diatoms and reproductive cells to embryos and organs. Cryopreserved biological samples mainly originate from mammals. Most cryopreservation trials using marine-derived AFPs have demonstrated that addition of AFPs can improve post-thaw viability regardless of freezing method (slow-freezing or vitrification), storage temperature, and types of biological sample type.
URI
http://repository.kopri.re.kr/handle/201206/6515
DOI
http://dx.doi.org/10.3390/md15020027
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