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Antioxidant, antibacterial activity and brine shrimp toxicity test of some mountainous lichens from Nepal

Cited 13 time in scopus
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Title
Antioxidant, antibacterial activity and brine shrimp toxicity test of some mountainous lichens from Nepal
Other Titles
네팔 산악지역 지의류의 항산화, 항균 효과 분석
Authors
Babita Paudel
Yim, Joung Han
Kim, Il-Chan
Hong, Soon Gyu
Hur, Jae-Seoun
Durga Prasad Pandey
Hari Datta Bhattarai
Subject
Life Sciences & Biomedicine - Other Topics
Keywords
Antibacterial; Antioxidant; Free radicals; Nepal lichens
Issue Date
2012
Publisher
SciELO
Citation
Babita Paudel, et al. 2012. "Antioxidant, antibacterial activity and brine shrimp toxicity test of some mountainous lichens from Nepal". BIOLOGICAL RESEARCH, 45(4): 387-391.
Abstract
A total of twenty four lichen species belonging to six families were collected from mountainous region of Nepal. The methanol extracts of each species were tested for antimicrobial and antioxidant activities in vitro. It was found that extracts of twenty one lichen species were active against B. subtilis and seven species were active against S. aureus. Similarly, in DPPH assay, three species Peltigera sp., Cladonia sp., and Canoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts of Parmoterma sp., Ramalina sp., Peltigera sp. and Cladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant and antibacterial constituents. Similarly, the methanol extracts of Heterodermia sp. and Ramalina sp. showed comparable toxicity eff ect with commercial standard berberine chloride indicating a potent source of anticancer drugs.racts of twenty one lichen species were active against B. subtilis and seven species were active against S. aureus. Similarly, in DPPH assay, three species Peltigera sp., Cladonia sp., and Canoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts of Parmoterma sp., Ramalina sp., Peltigera sp. and Cladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant and antibacterial constituents. Similarly, the methanol extracts of Heterodermia sp. and Ramalina sp. showed comparable toxicity eff ect with commercial standard berberine chloride indicating a potent source of anticancer drugs.
URI
http://repository.kopri.re.kr/handle/201206/6532
DOI
http://dx.doi.org/10.4067/S0716-97602012000400010
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