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Studies on the Effect of Number of Sugar Moiety in the Antifreeze Activityof Homodimeric AFGPs

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Title
Studies on the Effect of Number of Sugar Moiety in the Antifreeze Activityof Homodimeric AFGPs
Other Titles
AFGP 의 결빙방지활성과 결합된 당 갯수와의 상관관계 연구
Authors
Kim, Hak Jun
Shin Won Kang
Ravichandran N. Murugan
Hee Jung Park
Song Yub Shin
Mija Ahn
Chaejoon Cheong
Lee, Jun Hyuck
Eunjung Kim
Jeong Kyu Bang
Subject
Chemistry
Keywords
Antifreeze glycoproteins (AFGP; Carbohydrate; Hexagonal bipyramid; Ice morphology; Thermal hysteresis activity
Issue Date
2012
Publisher
Korean Chemical Society
Citation
Kim, Hak Jun, et al. 2012. "Studies on the Effect of Number of Sugar Moiety in the Antifreeze Activityof Homodimeric AFGPs". BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 33: 2411-2414.
Abstract
Antifreeze glycoproteins (AFGPs) are found in the plasma of deep sea polar fish such as the Antarctic nototheioids and the northern cods. The AFGPs consists of repeating tripeptides unite, Alanyl -Alanyl-Threonyl (Ala-Ala- Thr)n=4-50 unites, connected with the disaccharide β-D- galactosyl-(1→3)-α-D-N-acetylgalactosamine through a glycosidic bond at the second hydroxyl group of the threonine residue. Eight distinct AFGP subtypes exist. Among them, AFGP1 is the largest weight (33.7 kDa) and AFGP 8 is the lowest molecular weight (2.6 kDa). AFGPs are able to depress the freezing temperature of the blood serum in fish enough to keep them from freezing in their sub- zero environment while the melting temperature remains unchanged.Despite AFGPs have been consider as a potent cryopreservation, obstacle to develop AFGPs as medicinal and industrial application is mainly due to the problem of understanding how AFGPs inhibit ice crystal growth.To investigate the effect of number of hydroxyl group on antifreeze activity, we designed and synthesized the dimeric AFGP.ites, connected with the disaccharide β-D- galactosyl-(1→3)-α-D-N-acetylgalactosamine through a glycosidic bond at the second hydroxyl group of the threonine residue. Eight distinct AFGP subtypes exist. Among them, AFGP1 is the largest weight (33.7 kDa) and AFGP 8 is the lowest molecular weight (2.6 kDa). AFGPs are able to depress the freezing temperature of the blood serum in fish enough to keep them from freezing in their sub- zero environment while the melting temperature remains unchanged.Despite AFGPs have been consider as a potent cryopreservation, obstacle to develop AFGPs as medicinal and industrial application is mainly due to the problem of understanding how AFGPs inhibit ice crystal growth.To investigate the effect of number of hydroxyl group on antifreeze activity, we designed and synthesized the dimeric AFGP.
URI
http://repository.kopri.re.kr/handle/201206/6551
DOI
http://dx.doi.org/10.5012/bkcs.2012.33.7.2411
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