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Antibacterial Activities of Ramalin, Usnic Acid and its ThreeDerivatives Isolated from the Antarctic Lichen Ramalinaterebrata

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Title
Antibacterial Activities of Ramalin, Usnic Acid and its ThreeDerivatives Isolated from the Antarctic Lichen Ramalinaterebrata
Other Titles
남극 지의류 Ramalina terebrata 유래 신규 화합물 Ramalin, Usnic Acid 3개 유도체 의 항생활성
Authors
Babita Paudela
Hari Datta Bhattarai
Hyun Woung Shin
Yim, Joung Han
Hyuncheol Oh
Lee, Hong Kum
Keywords
Antarctic Lichen; Antimicrobial; Ramalina terebrata; Usnic Acid
Issue Date
2010
Citation
Babita Paudela, et al. 2010. "Antibacterial Activities of Ramalin, Usnic Acid and its ThreeDerivatives Isolated from the Antarctic Lichen Ramalinaterebrata". ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 65(1-2): 34-38.
Abstract
The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method while the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 μg/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis.
URI
http://repository.kopri.re.kr/handle/201206/6609
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