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A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7

Cited 4 time in scopus
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Title
A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7
Other Titles
대식세포 RAW 264.7에서 저온해수 서식 성게로부터 분리된 sulfonic acid derivative의 JNK/p38 MAPK와 NF-kB 불활성화를 통한 항염증 효과
Authors
Yim, Joung Han
이동성
Xiang Cui
Ko, Wonmin
Kim, Kyung Soo
Ren-Bo An
김윤철
Oh, Hyuncheol
Kim, Il-Chan
Keywords
(Z)-4-Methylundeca-1; 9-diene-6-sulfonicacid; A new sulfonic acidderivative; Anti-inflammation; Nuclear factor-kB; Sea urchin
Issue Date
2014
Citation
Yim, Joung Han, et al. 2014. "A new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid, isolated from the cold water sea urchin inhibits inflammatory responses through JNK/p38 MAPK and NF-κB inactivation in RAW 264.7". ARCHIVES OF PHARMACAL RESEARCH, 37(8): 983-991.
Abstract
In this study, we isolated a new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6-sulfonic acid (1), from the sea urchin collected from the Sea of Okhotsk. We established the structure of this new compound by analysis of NMR and HRMS data, along with comparison of the data with those of the related compounds reported in the literature. In addition, we investigated its anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages. Compound 1 inhibited the production of NO, iNOS, PGE2, and COX-2, and it also suppressed the production of proinflammatory cytokines, such as TNF-a and IL-1b. It inhibited the translocation of the NF-jB subunit p65 into the nucleus by interrupting the phosphorylation and degradation of IjB-a. In addition, compound 1 significantly decreased the phosphorylation of JNK and p38 in LPSstimulated RAW264.7 macrophages, suggesting that suppression of the inflammation process by compound 1 was mediated through the MAPK pathway. Taken together, this study showed that the anti-inflammatory effects of a new sulfonic acid derivative, (Z)-4-methylundeca-1,9-diene-6- sulfonic acid were mediated through the inhibition of NFjB and JNK/p38 MAPK signaling pathways.
URI
http://repository.kopri.re.kr/handle/201206/7250
DOI
http://dx.doi.org/10.1007/s12272-013-0269-1
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