KOPRI Repository

Characterization of Toll-like receptor gene expression and the pathogen agonist response in the antarctic bullhead notothen Notothenia coriiceps

Cited 9 time in wos
Cited 9 time in scopus

Full metadata record

DC Field Value Language
dc.contributor.authorShin, Seung Chul-
dc.contributor.authorAhn, Do Hwan-
dc.contributor.authorPark, Hyun-
dc.date.accessioned2018-03-29T06:02:12Z-
dc.date.available2018-03-29T06:02:12Z-
dc.date.issued2014-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/7284-
dc.description.abstractNotothenia coriiceps, a typical Antarctic notothenioid teleost, has evolved to adapt to the extreme Antarctic marine environment. We previously reported an extensive analysis of the Antarctic notothenioid transcriptome. In this study, we focused on a key component of the innate immune system, the Toll-like receptors (TLRs). We cloned the full-length sequence of 12 TLRs of N. coriiceps. The ncTLR genes encode a typical TLR structure, with multiple extracellular leucine-rich regions and an intracellular Toll/IL-1 receptor (TIR) domain. Using phylogenetic analysis, we established that all of the cloned ncTLR genes could be classified into the same orthologous clade with other teleost TLRs. ncTLRs were widely expressed in various organs, with the highest expression levels observed in immune-related tissues, such as skin, spleen, and kidney. A subset of the ncTLR genes were expressed at higher levels in fish exposed to pathogen-mimicking agonists, heat-killed E. coli and poly(I:C). However, the mechanism involved in the upregulation of TLR expression following pathogen exposure in fish is currently unknown. Further research is required to elucidate these mechanisms and to thereby increase our understanding of vertebrate immune system evolution.-
dc.languageEnglish-
dc.titleCharacterization of Toll-like receptor gene expression and the pathogen agonist response in the antarctic bullhead notothen Notothenia coriiceps-
dc.title.alternative남극어류의 Toll-Like Receptor 유전자 특성-
dc.typeArticle-
dc.identifier.bibliographicCitationShin, Seung Chul, Ahn, Do Hwan, Park, Hyun. 2014. "Characterization of Toll-like receptor gene expression and the pathogen agonist response in the antarctic bullhead notothen Notothenia coriiceps". <em>IMMUNOGENETICS</em>.-
dc.citation.titleIMMUNOGENETICS-
dc.identifier.doi10.1007/s00251-014-0792-3-
dc.description.articleClassificationSCI-
dc.description.jcrRateJCR 2012:42.236-
dc.subject.keywordAntarctic fish-
dc.subject.keywordToll-like receptors-
dc.subject.keywordimmune system-
dc.identifier.localId2014-0142-
dc.identifier.scopusid2-s2.0-84908236229-
dc.identifier.wosid000341835800005-
Appears in Collections  
2014-2016, Antarctic Organisms: Cold-Adaptation Mechanism and Its Application (14-16) / Park; Hyun (PE14070; PE15070; PE16070)
Files in This Item

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse