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Identification of three doublesex genes in the monogonont rotiferBrachionus koreanus and their transcriptional responses toenvironmental stressor-triggered population growth retardation

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Title
Identification of three doublesex genes in the monogonont rotiferBrachionus koreanus and their transcriptional responses toenvironmental stressor-triggered population growth retardation
Other Titles
로티퍼(Brachionus koreanus)에서 세개의 doublesex 유전자 동정과 환경적 스트레스 요인에 의해 유발된 집단의 성장지연에 대한 전사적 반응 연구
Authors
Kim, Bo-Mi
Lee, Jae-Seong
Jae-Sung Rhee
Lee, Yong Sung
Yim, Joung Han
Kim, Il-Chan
정창범
Keywords
B[a]P; Brachionus koreanus; DM-domain; Dmit; UV-B
Issue Date
2014
Citation
Kim, Bo-Mi, et al. 2014. "Identification of three doublesex genes in the monogonont rotiferBrachionus koreanus and their transcriptional responses toenvironmental stressor-triggered population growth retardation". COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 174(1): 36-44.
Abstract
Doublesex and Mab-3-related transcription factor (Dmrt) gene family members have rarely been identified or characterized in aquatic invertebrates. In this study, we identified and characterized three DMdomain-containing genes ? Dmrt11E, Dmrt93B, and Dmrt99B ? in themonogonont rotifer, Brachionus koreanus. DMdomains of the proteins encoded by the B. koreanus Dmrt (Bk-Dmrt) genes had high similarities to DM domains of other invertebrate species. To understand the potential effects of environmental stressors on the transcriptional expression of Dmrt genes in rotifers, we exposed B. koreanus to a wide range of UV-B radiation and different concentrations of benzo [a]pyrene (B[a]P) over different time courses. Transcript levels of all Bk-Dmrt genes decreased significantly in response to relatively high doses of UV-B irradiation, and were also downregulated in response to exposure to UV-B radiation over time. Transcript levels of all Bk-Dmrt genes were downregulated in response to B[a]P exposure for 24 h. This decrease in expression of all Bk-Dmrt genes was concomitant with the growth retardation induced by UV-B and B[a]P exposure.We concluded that both environmental stressors have detrimental effects on transcriptional regulation of all Bk-Dmrt genes, especially relatively high doses of these stressors, leading to growth retardation. However, further studies are required to better understand the potential role of Dmrt genes in environmental stressor-triggered growth retardation in the rotifer B. koreanus.
URI
http://repository.kopri.re.kr/handle/201206/7309
DOI
http://dx.doi.org/10.1016/j.cbpb.2014.05.003
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