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Anti-Inflammatory Effect of Methylpenicinoline from a MarineIsolate of Penicillium sp. (SF-5995): Inhibition of NF-κB andMAPK Pathways in Lipopolysaccharide-Induced RAW264.7Macrophages and BV2 Microglia

Cited 18 time in scopus
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Title
Anti-Inflammatory Effect of Methylpenicinoline from a MarineIsolate of Penicillium sp. (SF-5995): Inhibition of NF-κB andMAPK Pathways in Lipopolysaccharide-Induced RAW264.7Macrophages and BV2 Microglia
Other Titles
해양기원 Penicillium sp. (SF-5995)로부터 분리된 Methylpenicinoline의 항염증 효과
Authors
Kim, Dong-Cheol
Oh, Hyuncheol
김윤철
Yim, Joung Han
Sohn, Jae Hak
이동성
Ko, Wonmin
이희숙
Keywords
Penicillium sp.; anti-inflammation; methylpenicinoline; mitogen-activated protein kinase (MAPK); nuclearfactor-kappa B (NF-κB)
Issue Date
2014
Citation
Kim, Dong-Cheol, et al. 2014. "Anti-Inflammatory Effect of Methylpenicinoline from a MarineIsolate of Penicillium sp. (SF-5995): Inhibition of NF-κB andMAPK Pathways in Lipopolysaccharide-Induced RAW264.7Macrophages and BV2 Microglia". MOLECULES, 19(11): 18073-18089.
Abstract
In the course of a search for anti-inflammatory metabolites from marine-derived fungi, methylpenicinoline (1) was isolated from a marine isolate of Penicillin sp. Compound 1 inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production by suppressing the expression of inducible NO synthase (iNOS) in RAW264.7 macrophages and BV2 microglia. It also attenuated prostaglandin E2 (PGE2) production by suppressing cyclooxygenase-2 (COX-2) expression in a concentration-dependent manner (from 10 μM to 80 μM) without affecting cell viability. In addition, compound 1 reduced the production of the pro-inflammatory cytokine interleukin-1β (IL-1β). In a further study designed to elucidate the mechanism of its anti-inflammatory effects, compound 1 was shown to block nuclear factor-kappa B (NF-κB) activation in LPS-induced RAW264.7 macrophages and BV2 microglia by inhibiting the phosphorylation of inhibitor kappa B-α (IκB-α), thereby suppressing the nuclear translocation of NF-κB dimers, namely p50 and p65, that are known to be crucial molecules associated with iNOS and COX-2 expression. In addition, compound 1 inhibited the activation of mitogen-activated protein kinase (MAPK) pathways. Taken together, the results suggest that compound 1 might be a valuable therapeutic agent for the treatment of anti-inflammatory and anti-neuroinflammatory diseases.
URI
http://repository.kopri.re.kr/handle/201206/7317
DOI
http://dx.doi.org/10.3390/molecules191118073
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