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Tanzawaic acid derivatives from a marine isolate of Penicilliumsp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities

Cited 35 time in wos
Cited 38 time in scopus

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dc.contributor.authorTran Hong Quang-
dc.contributor.authorOh, Hyuncheol-
dc.contributor.author김윤철-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorSohn, Jae Hak-
dc.contributor.authorYoon, Chi-Su-
dc.contributor.authorKim, Dong-Cheol-
dc.contributor.authorKo, Wonmin-
dc.contributor.authorNguyen Thi Thanh Ngan-
dc.date.accessioned2018-03-29T06:03:53Z-
dc.date.available2018-03-29T06:03:53Z-
dc.date.issued2014-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/7318-
dc.description.abstractChemical investigation of a marine-derived fungus Penicillium sp. SF-6013 resulted in the discovery of a new tanzawaic acid derivative, 2E,4Z-tanzawaic acid D (1), togetherwith four known analogues, tanzawaic acids A (2) and D (3), a salt form of tanzawaic acid E (4), and tanzawaic acid B (5). Their structures were mainly determined by analysis of NMR and MS data, along with chemical methods. Preliminary screening for anti-inflammatory effects in lipopolysaccharide (LPS)-activated microglial BV-2 cells showed that compounds 1, 2, and 5 inhibited the production of nitric oxide (NO) with IC50 values of 37.8, 7.1, and 42.5 lM, respectively. Compound 2 also inhibited NO production in LPS-stimulated RAW264.7 murine macrophages with an IC50 value of 27.0 lM. Moreover, these inhibitory effects correlated with the suppressive effect of compound 2 on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in LPS-stimulated RAW264.7 and BV2 cells. In addition, compounds 2 and 5 significantly inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with the same IC50 value (8.2 lM).-
dc.languageEnglish-
dc.titleTanzawaic acid derivatives from a marine isolate of Penicilliumsp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities-
dc.title.alternative항염증과 PTP1B 억제활성을 가진 해양기원 Penicillium sp. (SF-6013) 균주로부터 Tanzawaic acid derivative들의 연구-
dc.typeArticle-
dc.identifier.bibliographicCitationTran Hong Quang, et al. 2014. "Tanzawaic acid derivatives from a marine isolate of Penicilliumsp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities". <em>BIOORGANIC & MEDICINAL CHEMISTRY LETTERS</em>, 24(24): 5787-5791.-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume24-
dc.citation.number24-
dc.identifier.doi10.1016/j.bmcl.2014.10.035-
dc.citation.startPage5787-
dc.citation.endPage5791-
dc.description.articleClassificationSCI-
dc.description.jcrRateJCR 2012:49.152-
dc.subject.keywordAnti-inflammatory-
dc.subject.keywordMarine-derived fungus-
dc.subject.keywordPTP1B-
dc.subject.keywordPenicillium-
dc.identifier.localId2014-0332-
dc.identifier.scopusid2-s2.0-84911895575-
dc.identifier.wosid000345581300050-
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
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