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Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters

Cited 3 time in scopus
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Title
Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters
Other Titles
리파아제-촉매를 이용한 6-O-cinnamoyl-sorbitolfrom D-sorbitol와 Cinnamic Acid Esters 생산
Authors
Kim, Jung-Ho
Yang, Yung-Hun
Lee, Yoo Kyung
김광진
최권영
이주희
김현중
Yi, Da-Hye
Seo, Hyung Min
유동원
Shashi Kant Bhatia
Keywords
6-O-cinnamoyl-sorbitol; Candida antarctica; Enzymatic synthesis; Lipase; Sorbitol
Issue Date
2015
Citation
Kim, Jung-Ho, et al. 2015. "Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters". APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 176(1): 244-252.
Abstract
To overcome the poor properties of solubility and stability of cinnamic acid, cinnamate derivatives with sugar alcohols were produced using the immobilized Candida antarctica lipase with vinyl cinnamate and D-sorbitol as substrate at 45 °C. Immobilized C. antarctica lipase was found to synthesize 6-O-cinnamoyl-sorbitol and confirmed by HPLC and 1H-NMR and had a preference for vinyl cinnamate over other esters such as allyl-, ethyl-, and isobutyl cinnamate as co-substrate with D-sorbitol. Contrary to D-sorbitol, vinyl cinnamate, and cinnamic acid, the final product 6-O-cinnamoyl-sorbitol was found to have radical scavenging activity. This would be the first report on the biosynthesis of 6-Ocinnamoyl- sorbitol with immobilized enzyme from C. antarctica.
URI
http://repository.kopri.re.kr/handle/201206/7367
DOI
http://dx.doi.org/10.1007/s12010-015-1570-x
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