KOPRI Repository

Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum

Cited 16 time in wos
Cited 16 time in scopus
Title
Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum
Other Titles
Endophytic Fungus Chaetomium globosum 으로 부터 생리활성의 아자필론 및 차에토비리딘의 완전한 구조 결정
Authors
Youn, Ui Joung
Leng Chee Chang
John M. Pezzuto
Dianqing Sun
Marisa M. Wall
Charles J. Simmons
Nighat Fatima
Tamara P. Kondratyuk
Eun-Jung Park
Tawanun Sripisut
Keywords
Chaetomium globosumWikstroemia uba-ursiX-ray crystallographyanti-inflammatory activityazaphilone
Issue Date
2015
Citation
Youn, Ui Joung, et al. 2015. "Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21): 4719-4723.
Abstract
Chemical investigation of an endophytic fungus Chaetomium globosum isolated from leaves of Wikstroemia uva-ursi led to the isolation of two new azaphilones, chaetoviridins J and K (1 and 3), along with five known derivatives (2 and 4?7). The structures of azaphilones were determined by NMR, X-ray diffraction, Mosher's method, and CD analysis. The isolated compounds were evaluated for their cancer chemopreventive-potential based on their abilities to inhibit tumor necrosis factor alpha (TNF-α)-induced nuclear factor-kappa B (NF-κB). Compounds 4, 5, 7, and synthetic 8 and 9 inhibit nitric oxide (NO) production with IC50 values in the range of 0.3?5.8 ?M. Compounds 4, 5, and 9 also displayed (TNF-α)-induced NF-κB activity with IC50 values in the range of 0.9?5.1 ?M.
URI
https://repository.kopri.re.kr/handle/201206/7392
DOI
http://dx.doi.org/10.1016/j.bmcl.2015.08.063
Type
Article
Indexed
SCI
Appears in Collections  
2011-2016, Exploration of Future Resources in The Polar Oceans and Study on Their Utilization (K-POD) (11-16) / Yim; Joung Han (PM11090; PM12030; PM13030; PM14050; PM15050)
Files in This Item

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse