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Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia

Cited 12 time in scopus
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Title
Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia
Other Titles
Dihydroisocoumarin 유도체의 항염증효과
Authors
Dong-Cheol Kim
Hyuncheol Oh
Youn-Chul Kim
Yongsheng Che
Yu Feng
Yim, Joung Han
Jae Hak Sohn
Chi-Su Yoon
Nguyen Thi Thanh Ngan
Tran Hong Quang
Keywords
Anti-inflammatory Effects; Dihydroisocoumarin; Marine-Derived Fungal
Issue Date
2015
Citation
Dong-Cheol Kim, et al. 2015. "Dihydroisocoumarin Derivatives from Marine-Derived Fungal Isolates and Their Anti-inflammatory Effects in Lipopolysaccharide-Induced BV2 Microglia". JOURNAL OF NATURAL PRODUCTS, 78(12): 2948-2955.
Abstract
Chemical investigation of the EtOAc extracts of marine-derived fungal isolates Aspergillus sp. SF-5974 and Aspergillus sp. SF-5976 yielded a new dihydroisocoumarin derivative (1) and 12 known metabolites. The structures of the isolated metabolites were established by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Among the metabolites, the absolute configuration of 5′-hydroxyasperentin (6) was determined by single-crystal X-ray diffraction analysis. The in vitro antineuroinflammatory effects of the metabolites were also evaluated in lipopolysaccharide (LPS)- stimulated microglial cells. Among the isolated metabolites, dihydroisocoumarin derivatives 1?6 (10?80 μM) were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated BV2 microglia. Further, 1 (20?80 μM) was found to suppress the phosphorylation of the inhibitor of nuclear factor kappa B-α (IκB-α), interrupt the nuclear translocation of nuclear factor kappa B (NF-κB), and decrease the activation of p38 mitogen-activated protein kinase (MAPK).
URI
http://repository.kopri.re.kr/handle/201206/7414
DOI
http://dx.doi.org/10.1021/acs.jnatprod.5b00614
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