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Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates

Cited 8 time in scopus
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Title
Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates
Other Titles
발효된 노니 쥬스로부터 항염증 및 퀴논 환원유도 화합물들
Authors
Youn, Ui Joung
Leng Chee Chang
John M. Pezzuto
Yanzhang Wei
Marisa M. Wall
Mayuramas Sang-Ngern
Tamara P.Kondratyuk
Eun-Jung Park
Keywords
Iridoid glycoside; Morinda citrifolia; antiinflammatory acitity
Issue Date
2016
Citation
Youn, Ui Joung, et al. 2016. "Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates". JOURNAL OF NATURAL PRODUCTS, 79(6): 1508-1513.
Abstract
A new fatty acid ester disaccharide, 2-O-(β-D-glucopyranosyl)-1-O-(2E,4Z,7Z)-deca-2,4,7-trienoyl-β-D-glucopyranose (1), a new ascorbic acid derivative, 2-caffeoyl-3-ketohexulofuranosonic acid γ-lactone (2), and a new iridoid glycoside, 10-dimethoxyfermiloside (3), were isolated along with thirteen known compounds (4?16) from fermented noni fruit juice (Morinda citrifolia). The structures of the new compounds, together with 4 and 5 were determined by 1D- and 2D- NMR experiments, as well as comparison with published values. Compounds 2 and 7 showed moderate inhibitory activities in a TNF-α-induced NF-κB assay and compounds 4 and 6 exhibited considerable quinone reductase-1 (QR1)-inducing effects.
URI
http://repository.kopri.re.kr/handle/201206/7477
DOI
http://dx.doi.org/10.1021/acs.jnatprod.5b00970
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