KOPRI Repository

Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis

Cited 2 time in scopus
Metadata Downloads
Title
Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis
Other Titles
Gardenia sootepensis의 끝눈에서 분리된 항염증 트라이터펜화합물들
Authors
Youn, Ui Joung
Leng Chee Chang
John M. Pezzuto
Surat Laphookhieo
Tawanun Sripisut
Tamara P. Kondratyuk
Park, Eun Jung
Keywords
Gardenia sootepenesis; anti-inflammatory activity; cycloartane triterpenes
Issue Date
2016
Citation
Youn, Ui Joung, et al. 2016. "Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis". FITOTERAPIA, 114: 92-97.
Abstract
Bioassay-guided fractionation of the dichloromethane extract from the apical bud of Gardenia sootepenesis Hutch. (Rubiaceae) led to the isolation of four new cycloartane triterpenes, sootepins F?I (1?4), along with four known derivatives (5?8). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison of the physicochemical data with published values. The isolates were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α)-induced nuclear factor kappa (NF-κB) activity. Compounds 6?8 inhibited TNF-α-induced NF-κB activity with half maximal inhibitory concentration (IC50) values of 8.3, 5.6, and 6.0 ?M, respectively;compounds 7 and 8 showed significant NO-inhibitory activity with IC50 values of 3.2 and 2.0 ?M, respectively.
URI
http://repository.kopri.re.kr/handle/201206/7480
DOI
http://dx.doi.org/10.1016/j.fitote.2016.08.012
Files in This Item
General Conditions
      ROMEO Green
    Can archive pre-print and post-print or publisher's version/PDF
      ROMEO Blue
    Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
      ROMEO Yellow
    Can archive pre-print (ie pre-refereeing)
      ROMEO White
    Archiving not formally supported

    qrcode

    Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

    Browse