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Isolation of secondary metabolites from an Arctic bacterium, Pseudomonas aeruginosa and their antimicrobial activities

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Title
Isolation of secondary metabolites from an Arctic bacterium, Pseudomonas aeruginosa and their antimicrobial activities
Other Titles
북극유래 박테리아, Pseudomonas aeruginosa로부터 대사산물들의 분리 및 항진균 활성
Authors
Youn, Ui Joung
Yim, Joung Han
Han, Se Jong
Kim, Min Ju
Keywords
Pseudomonas aeruginosa; antimicrobial activity; diketopiperazine
Issue Date
2016
Citation
Youn, Ui Joung, et al. 2016. "Isolation of secondary metabolites from an Arctic bacterium, Pseudomonas aeruginosa and their antimicrobial activities". Journal of microbiology, 52(4): 415-420.
Abstract
Chemical study of an Arctic bacterium, Pseudomonas aeruginosa (Pseudomonadaceae) led to the isolation of two diketopiperazines 1 and 2, two phenazine alkaloids 3 and 4, and an indole carbaldehyde 5, along with a benzoic acid derivative 6. The structures of the compounds were confirmed by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Among the isolates, compounds 5 and 6 were isolated for the first time from P. aeruginosa of the seawater of Arctic Chuckchi Sea. Antimicrobial activities of compounds 1?6 against a Staphylococcus aureus and Candida albicans were evaluated.
URI
http://repository.kopri.re.kr/handle/201206/7501
DOI
http://dx.doi.org/10.7845/kjm.2016.6058
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