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Biosynthesis of colored prodiginines from a new marine bacterium Hahella chejuensis KCTC2396

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Title
Biosynthesis of colored prodiginines from a new marine bacterium Hahella chejuensis KCTC2396
Other Titles
해양세균 하헬라 제주엔시스의 프로디지닌 생합성
Authors
이종석
Lee, Yoo Kyung
Kim, Dockyu
이충환
Oh, Tae Kwang
Kim, Ji Hyun
Park, Yeon-Kyung
Keywords
Hahella chejuensis; biosynthesis; prodiginine; prodigiosin; red pigment
Issue Date
2004
Citation
이종석, et al. 2004. Biosynthesis of colored prodiginines from a new marine bacterium Hahella chejuensis KCTC2396. 한국미생물연합회. 한국미생물연합회. 2004.10.21~.
Abstract
Hahella chejuensis KcrC2396 produces red pignent in the cell envelope, and the pigment was suspected to be composed of at least three components The main red-colored part was purified and identified as prodigiosin by NMR analysis, and the other was confirmed as norprodigiosin and undecylprodigiosin by com뼈ring with the well-known pigments from Sen'atia marcescense Nima and Streptomyces coelic%r A3(2), respectively. Interestingly, the three prodiginines (general name for a mother structure having three pyrrolyl rings with ditferent aì
kyl substituents) have not yet repoπed to be produced by same microorganism. Base on current data, KcrC2396 is thought to possess two separate pathways for the production of prodiginine. As prodigiosin is a promising drug showing immunosuppressive and algicidal etfects, the prodigiosin-biosynthetic pathway by KcrC2396 was studied through the structural analyses of accumulated intermediates. In addition, a fosmid clone containing the entire gene clusters for prodigiosin was sequenced anda detailed analysis ofthis clone is now in progress This work was supported by a grant from the 21 C Frontier Microbial Genomics and Applications Center.
URI
http://repository.kopri.re.kr/handle/201206/7548
Conference Name
한국미생물연합회
Conference Place
한국미생물연합회
Conference Date
2004.10.21~
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