DSpace Collection:https://repository.kopri.re.kr/handle/201206/134162026-04-16T00:08:35Z2026-04-16T00:08:35ZMass spectrometry-guided isolation of thiodiketopiperazines from 3 an EtOAc-extract of Setosphaeria rostrata culture medium and their 4 anti-skin aging effects on TNF-α-induced human dermal fibroblastsKwon, HaeunAnn, Hee WoonPark, SojungKwon, JaeyoungPark, KeunwanRyu, Seung MokGuo, YuanqiangYim, Joung HanKim, Il-ChanKim, Jae-JinShim, Sang HeeLee, SullimLee, Donghohttps://repository.kopri.re.kr/handle/201206/162172025-10-27T05:02:27Z2024-01-01T00:00:00ZTitle: Mass spectrometry-guided isolation of thiodiketopiperazines from 3 an EtOAc-extract of Setosphaeria rostrata culture medium and their 4 anti-skin aging effects on TNF-α-induced human dermal fibroblasts
Authors: Kwon, Haeun; Ann, Hee Woon; Park, Sojung; Kwon, Jaeyoung; Park, Keunwan; Ryu, Seung Mok; Guo, Yuanqiang; Yim, Joung Han; Kim, Il-Chan; Kim, Jae-Jin; Shim, Sang Hee; Lee, Sullim; Lee, Dongho
Abstract: Using mass spectrometry (MS)-guided isolation methods, a new thiodiketopiperazine derivative (1) and exserohilone (2)
11 were isolated from an EtOAc-extract of Setosphaeria rostrata culture medium. The chemical structure of the new compound
12 was elucidated by MS and NMR spectroscopy, and the absolute configurations were established by the quantum mechanical
13 calculations of electronic circular dichroism. All isolated compounds were examined for their effects on reactive oxygen
14 species (ROS) production, matrix metalloproteinase 1 (MMP-1) secretion, and procollagen type I α1 secretion in tumor
15 necrosis factor (TNF)-α-induced human dermal fibroblasts. Compound 1 and exserohilone (2) exhibited the inhibition of
16 TNF-α-induced ROS generation and MMP-1 secretion. Additionally, compound 1 and exserohilone (2) increased the
17 procollagen type I α1 secretion. Compound 1 docked computationally into the active site of MMP-1 (？6.0 kcal/mol).2024-01-01T00:00:00ZScreening of multi-functional psychrophilic lipase from polar microorganisms and synthesis of functional compoundKim, Hyung-kwounhttps://repository.kopri.re.kr/handle/201206/145212023-08-17T01:56:27Z2023-07-26T00:00:00ZTitle: Screening of multi-functional psychrophilic lipase from polar microorganisms and synthesis of functional compound
Authors: Kim, Hyung-kwoun2023-07-26T00:00:00ZMetabolomics and molecular networking based discovery of biomaterials derived from antarctic microorganismLee, Donghohttps://repository.kopri.re.kr/handle/201206/145402023-08-17T01:57:58Z2023-07-26T00:00:00ZTitle: Metabolomics and molecular networking based discovery of biomaterials derived from antarctic microorganism
Authors: Lee, Dongho2023-07-26T00:00:00ZStudy of polar environmental adaptation mechanism through analysis of nutrient metabolism and it related genome in the Antarctic copepodLee,Jae-Seonghttps://repository.kopri.re.kr/handle/201206/146252023-09-21T07:12:37Z2023-03-10T00:00:00ZTitle: Study of polar environmental adaptation mechanism through analysis of nutrient metabolism and it related genome in the Antarctic copepod
Authors: Lee,Jae-Seong2023-03-10T00:00:00Z