https://repository.kopri.re.kr/handle/201206/15851 2026-04-13T23:04:04Z 2026-04-13T23:04:04Z Jung, Han Young Jung, Hyun Wook Koo, Man Hyung Hong, Tae Hwa Kim, Dong Jun Lee, Jung Seok Lee, Yoon Hak Jang, Hyeonji Kim, Jin-Hyoung Kim, Sanghee Heo, Eun Jin Lee, Seulah Youn, Ui Joung Lee, Jung Tae https://repository.kopri.re.kr/handle/201206/16144 2025-10-22T02:30:18Z 2025-01-01T00:00:00Z

Title: An architecting binder derived from Antarctic red algae to accelerate sulfur redox kinetics in Li-S batteries Authors: Jung, Han Young; Jung, Hyun Wook; Koo, Man Hyung; Hong, Tae Hwa; Kim, Dong Jun; Lee, Jung Seok; Lee, Yoon Hak; Jang, Hyeonji; Kim, Jin-Hyoung; Kim, Sanghee; Heo, Eun Jin; Lee, Seulah; Youn, Ui Joung; Lee, Jung Tae Abstract: Volume changes during charge/discharge cycles can lead to substantial cracking, disrupting electron and ion transfer channels, and hindering the performance of lithium-sulfur (Li-S) batteries. Binders are crucial for mitigating these issues because they preserve the structural integrity of electrodes and ensure reliable operation. Herein, this study presents the first report of a hybrid carrageenan, Antarctic macroalgae Curdiea racovitzae-derived polysaccharide (CRP), consisting of a diverse-blocked copolymer including kappa, iota, mu, nu carrageenans, and porphyran as Li-S battery binders. CRP prevents binder agglomeration and enables the electrode to form a uniform 3D-network structure reminiscent of an ant tunnel, enhancing the electrolyte permeability and utilization of the sulfur species. Additionally, the abundant functional groups in CRP, such as sulfate and hydroxyl groups, facilitate efficient Li- ion transport. By leveraging these properties, the CRP-based sulfur electrode achieves a high initial capacity of similar to 1500 mAh g 1 at 0.1C, approximately 90 % of the theoretical capacity, and demonstrates superior cycle stability at 1C. Moreover, the Li2S nucleation rate was nearly 100 times higher compared to the PVDF-based sulfur electrode. The incorporation of a sustainable CRP binder in Li-S batteries marks a notable breakthrough, paving the way for future developments in the battery field.

2025-01-01T00:00:00Z Liu Zhiming Yoon Chi-Su Cao Thao Quyen Lee Hwan Kim, Il-Chan Yim, Joung Han Sohn Jae Hak Lee Dong-Sung Oh Hyuncheol https://repository.kopri.re.kr/handle/201206/16185 2025-10-24T02:38:12Z 2025-01-01T00:00:00Z

Title: Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus Aspergillus sp. Strain SF-7367 Authors: Liu Zhiming; Yoon Chi-Su; Cao Thao Quyen; Lee Hwan; Kim, Il-Chan; Yim, Joung Han; Sohn Jae Hak; Lee Dong-Sung; Oh Hyuncheol Abstract: Inflammation has always been considered a trigger or consequence of neurodegenerative diseases, and the inhibition of inflammation in the central nervous system can effectively protect nerve cells. Several studies have indicated that various natural products inhibit neuroinflammation. Among these, Antarctic fungal metabolites have pharmacological activities and a developmental value. Therefore, this study aimed to evaluate the anti-neuroinflammatory activity of an Antarctic fungus belonging to Aspergillus (strain SF-7367). Secondary metabolites of SF-7367 were isolated using high-performance liquid chromatography followed by validation of their anti-inflammatory effects in lipopolysaccharide-stimulated BV2 microglia and RAW264.7 macrophages. Chemical analysis of metabolites from the fungal strain revealed five known compounds: epideoxybrevianamide E (1), brevianamide V/W (2), brevianamide K (3), brevianamide Q (4), and brevianamide R (5). Among these compounds, brevianamide K showed significant anti-inflammatory activity against both cell types. Results of Western blotting and molecular docking showed that brevianamide K could regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappa B) signaling. This indicates that brevianamide K present in Aspergillus sp. (strain SF-7367) can inhibit inflammatory responses by reducing lipopolysaccharide-induced nuclear translocation of NF-kappa B (p65). These findings suggest that Aspergillus sp. (strain SF-7367) and brevianamide K are candidate agents for treating neurodegenerative diseases.

2025-01-01T00:00:00Z Kim Hyeonjin Lee, Yelim Yu Jihyeon Park Jong-Yoon Lee, Jungeun Kim Sang-Gyu Hyun Youbong https://repository.kopri.re.kr/handle/201206/16344 2025-11-05T08:20:20Z 2024-11-01T00:00:00Z

Title: Production of the antimalarial drug precursor amorphadiene by microbial terpene synthase-like from the moss Sanionia uncinata Authors: Kim Hyeonjin; Lee, Yelim; Yu Jihyeon; Park Jong-Yoon; Lee, Jungeun; Kim Sang-Gyu; Hyun Youbong Abstract: Main conclusionThe microbial terpene synthase-like of the moss Sanionia uncinata displays the convergent evolution of a rare plant metabolite amorpha-4,11-diene synthesis.AbstractDespite increasing demand for the exploration of biological resources, the diversity of natural compounds synthesized by organisms inhabiting various climates remains largely unexplored. This study focuses on the moss Sanionia uncinata, known as a predominant species within the polar climates of the Antarctic Peninsula, to systematically explore its metabolic profile both in-field and in controlled environments. We here report a diverse array of moss-derived terpene volatiles, including the identification of amorpha-4,11-diene, a rare sesquiterpene compound that is a precursor for antimalarial drugs. Phylogenetic reconstruction and functional validation in planta and in vitro identified a moss terpene synthase, S. uncinata microbial terpene synthase-like 2 (SuMTPSL2), which is associated with amorpha-4,11-diene production. We demonstrate that expressing SuMTPSL2 in various heterologous systems is sufficient to produce amorpha-4,11-diene. These results highlight the metabolic diversity in Antarctica, but also provide insights into the convergent evolution leading to the synthesis of a rare plant metabolite.

2024-11-01T00:00:00Z Kwon, Haeun Ann, Hee Woon Lee, Jin Su Kwon, Jaeyoung Park, Keunwan Guo, Yuanqiang Hwang, Bang Yeon Jae-Jin Kim Yim, Joung Han Kim, Il-Chan Jang, Dae Sik Lee, Sullim Lee, Dongho https://repository.kopri.re.kr/handle/201206/16582 2026-02-10T03:43:07Z 2024-11-01T00:00:00Z

Title: Two new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretion Authors: Kwon, Haeun; Ann, Hee Woon; Lee, Jin Su; Kwon, Jaeyoung; Park, Keunwan; Guo, Yuanqiang; Hwang, Bang Yeon; Jae-Jin Kim; Yim, Joung Han; Kim, Il-Chan; Jang, Dae Sik; Lee, Sullim; Lee, Dongho Abstract: A new cytosporin derivative (1) and a new phenolic compound (2), together with cytosporin D (3), were isolated from an EtOAc extract of Apiospora xenocordella culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structures of the new compounds were determined by using MS and NMR spectroscopic techniques, and the absolute configurations were established by the modified Mosher’s method and quantum chemical calculation of electronic circular dichroism. UV radiation activates pro-inflammatory cytokines, such as TNF-α, a major contributor to skin aging through ROS generation and MMP-1 secretion. Cytosporin D (3) exhibited the inhibition of TNF-α-induced ROS and MMP-1. UV radiation activates pro-inflammatory cytokines including TNF-α which is a major contributor to skin aging through reactive oxygen species (ROS) generation and matrix metalloproteinase-1 (MMP-1) secretion. Cytosporin D (3) exhibited moderate inhibition against TNF-α-induced ROS and MMP-1. This compound docked computationally into the active site of MMP-1 (？？ 5.9 kcal/mol). Compound 1, though not tested due to limited quantity, showed a docking simulation result (？？ 6.0 kcal/mol) similar to cytosporin D (3), indicating potential activity.

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