https://repository.kopri.re.kr/handle/201206/13410 2026-09-10T12:45:15Z https://repository.kopri.re.kr/handle/201206/14506 Title: Study on polar ecosystem change by warming and adaptation mechanisms of polar organism Authors: Kim, Sanghee 2023-07-26T00:00:00Z https://repository.kopri.re.kr/handle/201206/16971 Title: 테라노바만의 해빙 및 빙하 영향에 의한 해양저서생물의 군집 구조와 주요 우점종 개체군 변동 양상 추적 Authors: 박상율 2023-01-01T00:00:00Z https://repository.kopri.re.kr/handle/201206/14273 Title: High-Quality Genome Resource of a Novel Venturiaceae sp. KMAF11, Isolated from Diseased Colobanthus quitensis, an Antarctic Flowering Plant Authors: 김홍실; 유지현; Jesse Kaleku; 이예림; 박은숙; Lee, Hyoungseok; Kim, Han-Woo; Lee, Jungeun Abstract: In summary, a novel fungal strain, KMAF11, isolated from diseased Antarctic plants, is believed to belong to the Venturiaceae sp., a common phytopathogenic fungal group. This fungus may have been dormant in the leaves or rhizosphere of C. quitensis, an Antarctic flowering plant, but it is presumed to induce disease in C. quitensis due to a change in the habitat environment. Genomic information on latent pathogenic fungi associated with vascular plants in Antarctica has not yet been reported. In this study, we report the first high-quality genome dataset for this fungus. This dataset provides important information about the genes involved in the fungal lifestyle. Further studies of these genes will contribute to elucidating the molecular interactions between pathogenic fungi and plants inhabiting Earth’s extreme regions. 2023-01-01T00:00:00Z https://repository.kopri.re.kr/handle/201206/14302 Title: The Safety and Efficacy of 1-Monoeicosapentaenoin Isolated from the Trebouxiophyceae Micractinium on Anti-Wrinkle: A Split-Face Randomized, Double-Blind Placebo-Controlled Clinical Study Authors: Ki Mo Kim; Kon-Young Ji; Yoon Jung Choi; Jong Beom Heo; Youn, Ui Joung; Kim, Sanghee; Ki-Shuk Shim; Joo Young Lee; Tae Soo Kim; Young Kyoung Seo; Gyu-Yong So; Sungwook Cha Abstract: The skin aging process is governed by intrinsic and extrinsic factors causing skin wrinkles, sagging, and loosening. The 1-monoeicosapentaenoin (1-MEST) is a component isolated from Micractinium, a genus of microalgae (Chlorophyta, Trebouxiophyceae). However, the anti-wrinkle effects of 1-MEST are not yet known. This study aimed to evaluate the anti-wrinkle effects of 1-MEST in vitro and in clinical trials. The cytotoxicity of 1-MEST was investigated in vitro using the MTS assay in human epidermal keratinocytes (HEKs). Expression of matrix metalloproteinase (MMP)-1 and MMP-9 was determined by ELISA in HEKs irradiated with UVB after treatment with 1-MEST. A split-face randomized, double-blind, placebo-controlled study was conducted to evaluate the safety and efficacy of 1-MEST. The study evaluated wrinkle parameters and visual assessment, self-efficacy and usability questionnaires, and adverse events. The study showed that the 1-MEST was not cytotoxic in HEKs, suppressed MMP-1 secretion and MMP-9 protein expression in HEKs irradiated with UVB. The wrinkle parameters and mean visual assessment score were significantly decreased in the test group after 12 weeks and differed from the control group. There were no significant differences in efficacy and usability. Adverse effects were also not observed. The 1-MEST showed anti-wrinkle properties to slow down or prevent skin aging. 2023-01-01T00:00:00Z