https://repository.kopri.re.kr/handle/201206/15776 2026-04-11T14:06:41Z https://repository.kopri.re.kr/handle/201206/16562 Title: Anticancer activity of benzomalvin derivatives isolated from Penicillium spathulatum SF7354, a symbiotic fungus from Azorella monantha Authors: Jeon, Min Seo; Hong, Ju-Mi; Kim, Jaewon; Kim, Jina; Sojin Kim; Sohn, Jae Hak; Han, Se Jong; Yim, Joung Han; Kim, Il-Chan Abstract: Penicillium spathulatum SF7354 was isolated from the extremophilic plant Azorella monantha collected in Chilean Patagonia and investigated for its anticancer potential. Crude extracts of SF7354 exhibited significant cytotoxic activity against multiple human cancer cell lines, with the most pronounced effect observed in HCT116 cells. Flow cytometry analysis revealed that treatment with the extract induced time-dependent apoptosis and sub-G1 accumulation, indicating activation of programmed cell death. Cell cycle analysis further showed early G0/G1 arrest, followed by a progressive increase in apoptotic populations. Western blot analysis demonstrated notable alterations in PARP and p53 protein levels, suggesting a p53-dependent mechanism of apoptosis. HPLC-based purification of the extract led to the isolation of five benzomalvin derivatives (A？E), all of which exhibited dose- and time-dependent cytotoxicity. These findings suggest that SF7354-derived benzomalvins act through apoptosis-associated mechanisms and represent promising candidates for the development of novel anticancer agents. 2025-09-01T00:00:00Z https://repository.kopri.re.kr/handle/201206/16570 Title: CHEMICAL CONSTITUENTS AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL FROM THE LICHEN, Ramalina peruviana Authors: Youn, Ui Joung; Kim, Min Ju; Han, Se Jong Abstract: Essential oils are volatile compounds that commonly used in aromatherapy, personal care products, and medicinal purposes due to their various health benefits and aromatic qualities. However, only one report on essential oils from the genus Ramalina has been studied so far. To the best our knowledge, there are no reports on chemical compositions of essential oils from the lichen, R. peruviana. Here, we describe for the first time the chemical analysis on essential oils extracted from R. peruviana, together with its antimicrobial activity. 2025-09-01T00:00:00Z https://repository.kopri.re.kr/handle/201206/16085 Title: Study on the Establishment of Korean Names and Naming Principles for Antarctic Fish Species Authors: Kim, Jin-Hyoung; Kim, Eunjung; Kim, Il-Chan; Kim, Jeong-Hoon; Kim, Heeyong; Park, Jeongseok; Park, JeongHo Abstract: Fish inhabiting the Southern Ocean exhibit unique physiological and morphological adaptations to extreme environments and play a vital role in the ecosystem. However, in South Korea, the standardized Korean nomenclature for Antarctic fish species has not been systematically established, posing challenges for academic research and educational resource development. This study aims to establish Korean names for 147 species of fish inhabiting the Southern Ocean, including those with existing Korean names, and to present the principles and methodology applied in the naming process. Based on a review of existing literature, we examined the naming conventions employed by the National Institute of Fisheries Science (NIFS) and the Korea Polar Research Institute (KOPRI). We established naming principles that consider ecological and morphological characteristics. Furthermore, we ensured consistency by aligning the newly proposed names with internationally recognized scientific and English names. The results indicate that names reflecting habitat and morphological or ecological traits are effective in enhancing public understanding, and that maintaining continuity with existing Korean names is essential. This study is expected to contribute to future research on Antarctic fish and the development of educational resources.; 본 연구는 남극암치아목 (Notothenioidei)의 5개 과 (Family)에 속하는 남극 어류 147종에 대한 국문명을 제정하고, 과학적·언어적 일관성을 고려한 명명 원칙을 수립하였다. 특히 생태적·형태적 특성을 반영한 명명 기준을 도입함으로써 기존 명명 방식의 한계를 보완하고, 국제적인 조화를 고려한 명명 체계를 구축하였다. 향후 연구에서는 명명 과정에서 발생할 수 있는 문제점을 지속적으로 보완하고, 학술 및 교육 분야에서 활용될 수 있도록 추가적인 연구가 필요하다. 2025-08-01T00:00:00Z https://repository.kopri.re.kr/handle/201206/16126 Title: Isolation and characterization of low-temperature and high-salinity amylase from Halomonas sp. KS41843 Authors: Kim, Jin A; Kim, Min Ju; Yim, Joung Han; Kim, Il-Chan; Rhee, Jae-Sung; Han, Se Jong Abstract: The polar regions harbor uniquely diverse organisms adapted to low temperatures. Strains obtained from these regions are likely to produce enzymes that are industrially useful at low temperatures. In this study, a Halomonas sp. strain isolated from the Antarctic Sea was cultured at 15 °C to obtain partially purified α-amylase. This enzyme exhibited maximum activity at 30 °C and pH 5.0, retaining over 80 % of its maximum activity even at 5 °C. Its activity was > 1.5-fold in the presence of Co2+, Mn2+, Mg2+, Fe2+, and Na+, indicating enhancement by most metal ions. Halophilic strain-derived enzyme maintained up to 95 % of its maximum activity even at 4 M NaCl, highlighting its potential for industrial applications and possible cost savings. In this study, the low-temperature and high-salinity active amylase produced by Antarctic Halomonas sp. KS41843 was identified as a promising candidate for future biotechnology applications. 2025-08-01T00:00:00Z