DSpace Collection: https://repository.kopri.re.kr/handle/201206/13416 Thu, 16 Apr 2026 00:06:49 GMT 2026-04-16T00:06:49Z Mass spectrometry-guided isolation of thiodiketopiperazines from 3 an EtOAc-extract of Setosphaeria rostrata culture medium and their 4 anti-skin aging effects on TNF-α-induced human dermal fibroblasts https://repository.kopri.re.kr/handle/201206/16217 Title: Mass spectrometry-guided isolation of thiodiketopiperazines from 3 an EtOAc-extract of Setosphaeria rostrata culture medium and their 4 anti-skin aging effects on TNF-α-induced human dermal fibroblasts Authors: Kwon, Haeun; Ann, Hee Woon; Park, Sojung; Kwon, Jaeyoung; Park, Keunwan; Ryu, Seung Mok; Guo, Yuanqiang; Yim, Joung Han; Kim, Il-Chan; Kim, Jae-Jin; Shim, Sang Hee; Lee, Sullim; Lee, Dongho Abstract: Using mass spectrometry (MS)-guided isolation methods, a new thiodiketopiperazine derivative (1) and exserohilone (2) 11 were isolated from an EtOAc-extract of Setosphaeria rostrata culture medium. The chemical structure of the new compound 12 was elucidated by MS and NMR spectroscopy, and the absolute configurations were established by the quantum mechanical 13 calculations of electronic circular dichroism. All isolated compounds were examined for their effects on reactive oxygen 14 species (ROS) production, matrix metalloproteinase 1 (MMP-1) secretion, and procollagen type I α1 secretion in tumor 15 necrosis factor (TNF)-α-induced human dermal fibroblasts. Compound 1 and exserohilone (2) exhibited the inhibition of 16 TNF-α-induced ROS generation and MMP-1 secretion. Additionally, compound 1 and exserohilone (2) increased the 17 procollagen type I α1 secretion. Compound 1 docked computationally into the active site of MMP-1 (？6.0 kcal/mol). Mon, 01 Jan 2024 00:00:00 GMT https://repository.kopri.re.kr/handle/201206/16217 2024-01-01T00:00:00Z Screening of multi-functional psychrophilic lipase from polar microorganisms and synthesis of functional compound https://repository.kopri.re.kr/handle/201206/14521 Title: Screening of multi-functional psychrophilic lipase from polar microorganisms and synthesis of functional compound Authors: Kim, Hyung-kwoun Wed, 26 Jul 2023 00:00:00 GMT https://repository.kopri.re.kr/handle/201206/14521 2023-07-26T00:00:00Z Metabolomics and molecular networking based discovery of biomaterials derived from antarctic microorganism https://repository.kopri.re.kr/handle/201206/14540 Title: Metabolomics and molecular networking based discovery of biomaterials derived from antarctic microorganism Authors: Lee, Dongho Wed, 26 Jul 2023 00:00:00 GMT https://repository.kopri.re.kr/handle/201206/14540 2023-07-26T00:00:00Z Study of polar environmental adaptation mechanism through analysis of nutrient metabolism and it related genome in the Antarctic copepod https://repository.kopri.re.kr/handle/201206/14625 Title: Study of polar environmental adaptation mechanism through analysis of nutrient metabolism and it related genome in the Antarctic copepod Authors: Lee,Jae-Seong Fri, 10 Mar 2023 00:00:00 GMT https://repository.kopri.re.kr/handle/201206/14625 2023-03-10T00:00:00Z