KOPRI Repository

Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum

Cited 8 time in wos
Cited 8 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHong, Ju-Mi-
dc.contributor.authorSuh, Sung-Suk-
dc.contributor.authorKim, Tai Kyoung-
dc.contributor.authorKim, Jung Eun-
dc.contributor.authorHan, Se Jong-
dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorKim, Il-Chan-
dc.date.accessioned2020-04-24T08:42:28Z-
dc.date.available2020-04-24T08:42:28Z-
dc.date.issued2018-03-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/10512-
dc.description.abstractLobaric acid and lobarstin, secondary metabolites derived from the antarctic lichen Stereocaulon alpnum, exert various biological activities, including antitumor, anti-proliferation, anti-inflammation, and antioxidant activities. However, the underlying mechanisms of these effects have not yet been elucidated in human cervix adenocarcinoma and human colon carcinoma. In the present study, we evaluated the anticancer effects of lobaric acid and lobarstin on human cervix adenocarcinoma HeLa cells and colon carcinoma HCT116 cells. We show that the proliferation of Hela and HCT116 cells treated with lobaric acid and lobarstin significantly decreased in a dose- and time-dependent manner. Using flow cytometry analysis, we observed that the treatment with these compounds resulted in significant apoptosis in both cell lines, following cell cycle perturbation and arrest in G2/M phase. Furthermore, using immunoblot analysis, we investigated the expression of cell cycle and apoptosis-related marker genes and found a significant downregulation of the apoptosis regulator B-cell lymphoma 2 (Bcl-2) and upregulation of the cleaved form of the poly (ADP-ribose) polymerase (PARP), a DNA repair and apoptosis regulator. These results suggest that lobaric acid and lobarstin could significantly inhibit cell proliferation through cell cycle arrest and induction of apoptosis via the mitochondrial apoptotic pathway in cervix adenocarcinoma and colon carcinoma cells. Taken together, our data suggests that lobaric acid and lobarstin might be novel agents for clinical treatment of cervix adenocarcinoma and colon carcinoma.en_US
dc.languageEnglish-
dc.language.isoenen_US
dc.subjectBiochemistry & Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subject.classification해당사항없음en_US
dc.titleAnti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnumen_US
dc.title.alternative남극지의류(스테레오카울론)유래 이차대산물인 로바릭산, 로바스틴의 대장암과 자궁경부암에 대한 항암활성en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationHong, Ju Mi, et al. 2018. "Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum". <em>MOLECULES</em>, 23(3): 658-658.en_US
dc.citation.titleMOLECULESen_US
dc.citation.volume23en_US
dc.citation.number3en_US
dc.identifier.doi10.3390/molecules23030658-
dc.citation.startPage658en_US
dc.citation.endPage658en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2016:28.8135593220339en_US
dc.subject.keywordantartic lichenen_US
dc.subject.keywordapoptosisen_US
dc.subject.keywordcell cycle arresten_US
dc.subject.keywordhuman cervix adenocarcinomaen_US
dc.subject.keywordhuman colon carcinomaen_US
dc.subject.keywordlobaric aciden_US
dc.subject.keywordlobarstinen_US
dc.identifier.localId2018-0024-
dc.identifier.scopusid2-s2.0-85044355425-
dc.identifier.wosid000428514100149-
Appears in Collections  
2018-2018, Commercialization of useful metabolites from polar organisms (18-18) / Yim, Joung Han
2016-2018, Cryo-Biotech (16-18) / Yim, Joung Han; Han, Se Jong
Files in This Item
General Conditions
      ROMEO Green
    Can archive pre-print and post-print or publisher's version/PDF
      ROMEO Blue
    Can archive post-print (ie final draft post-refereeing) or publisher's version/PDF
      ROMEO Yellow
    Can archive pre-print (ie pre-refereeing)
      ROMEO White
    Archiving not formally supported

    Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

    Browse