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Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity

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dc.contributor.authorKim, Hyunji-
dc.contributor.authorKoo, Man Hyung-
dc.contributor.authorLee, Jun Hyuck-
dc.contributor.authorSuh, Sung-Suk-
dc.contributor.authorYoun, Ui Joung-
dc.date.accessioned2020-10-19T05:37:41Z-
dc.date.available2020-10-19T05:37:41Z-
dc.date.issued2019-09-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/10837-
dc.description.abstractPhytochemical study of Ganoderma lucidum (Polyporaceae) let to the isolation of five lanostane triterpenoid (1-5), along with two nitrogen derived phenolic compounds, N-phenylethylformamide (6) and N-acetylphenethylamine (7). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 6 and 7 were isolated for the first time from the genus Ganoderma and this species. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Among the isolates, compounds 2 and 3 showed moderate inhibitory activity against NO production.en_US
dc.formatapplication/pdf-
dc.languageKoreanen_US
dc.language.isokoen_US
dc.subjectPharmacology & Pharmacyen_US
dc.subject.classification기타en_US
dc.titleSecondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activityen_US
dc.title.alternative영지버섯(Ganoderma lucidum)으로 부터 분리한 이차대사산물 및 이들의 항 염증 활성en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationKim, Hyunji, et al. 2019. "Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity". <em>Korean Journal of Pharmacognosy</em>, 50(3): 232-238.-
dc.citation.titleKorean Journal of Pharmacognosyen_US
dc.citation.volume50en_US
dc.citation.number3en_US
dc.identifier.doihttp://www.koreascience.or.kr/article/JAKO201928951542984.page-
dc.citation.startPage232en_US
dc.citation.endPage238en_US
dc.description.articleClassificationKCI등재-
dc.description.jcrRateJCR 2017:0en_US
dc.subject.keywordAnti-inflammatoryen_US
dc.subject.keywordGanoderma lucidumen_US
dc.subject.keywordLanstane triterpenoiden_US
dc.subject.keywordPolyporaceaeen_US
dc.identifier.localId2019-0372-
dc.identifier.scopusid2-s2.0-85076293375-
Appears in Collections  
2019-2019, Development of potential candidates as antibiotics based on polar genetic resources (19-19) / Lee, Jun Hyuck (PE19210)
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