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Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum

Cited 5 time in wos
Cited 5 time in scopus
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dc.contributor.authorKim, Tai Kyoung-
dc.contributor.authorKim, Joung Eun-
dc.contributor.authorYoun, Ui Joung-
dc.contributor.authorHan, Se Jong-
dc.contributor.authorKim, Il-Chan-
dc.contributor.authorCho, Cheon-Gyu-
dc.contributor.authorYim, Joung Han-
dc.date.accessioned2020-10-19T07:36:46Z-
dc.date.available2020-10-19T07:36:46Z-
dc.date.issued2018-06-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/10841-
dc.description.abstractThe first total syntheses of the natural products lobaric acid and its derivatives isolated from the Antarctic lichen, Stereocaulon alpinum are reported in this study. Lobarin with a pseudodepsidone structure was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.en_US
dc.languageEnglishen_US
dc.language.isoenen_US
dc.subjectPlant Sciencesen_US
dc.subjectPharmacology & Pharmacyen_US
dc.subject.classificationKing Sejong Stationen_US
dc.titleTotal Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinumen_US
dc.title.alternative지의류 Stereocaulon alpinum 에서 추출된 로바릭산과 그 유도체들의 전합성연구en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationKim, Tai Kyoung, et al. 2018. "Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum". <em>JOURNAL OF NATURAL PRODUCTS</em>, 81(6): 1460-1467.en_US
dc.citation.titleJOURNAL OF NATURAL PRODUCTSen_US
dc.citation.volume81en_US
dc.citation.number6en_US
dc.identifier.doi10.1021/acs.jnatprod.8b00227-
dc.citation.startPage1460en_US
dc.citation.endPage1467en_US
dc.description.articleClassificationSCI-
dc.description.jcrRateJCR 2016:15.5660377358491en_US
dc.subject.keywordLobaric aciden_US
dc.subject.keywordPTP1B inhibitionen_US
dc.subject.keywordStereocaulon alpinumen_US
dc.subject.keyword극지 지의류en_US
dc.subject.keyword극지 천연물en_US
dc.subject.keyword유기 화학en_US
dc.subject.keyword지의류 유래 대사체en_US
dc.subject.keyword천연물 화학en_US
dc.identifier.localId2018-0061-
dc.identifier.scopusid2-s2.0-85049007180-
dc.identifier.wosid000436527100019-
Appears in Collections  
2018-2018, Commercialization of useful metabolites from polar organisms (18-18) / Yim, Joung Han (PE18100)
2016-2018, Cryo-Biotech (16-18) / Yim, Joung Han; Han, Se Jong (PE16190; PE17100; PE18100)
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