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Effect of growth rate on transcriptomic responses to immune stimulation in wild-type, domesticated, and GH-transgenic coho salmon

Cited 7 time in wos
Cited 9 time in scopus

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dc.contributor.authorKim, Jin-Hyoung-
dc.contributor.authorMacqueen, Daniel J.-
dc.contributor.authorWinton, James R.-
dc.contributor.authorHansen, John D.-
dc.contributor.authorPark, Hyun-
dc.contributor.authorDevlin, Robert H.-
dc.date.accessioned2020-10-21T04:49:49Z-
dc.date.available2020-10-21T04:49:49Z-
dc.date.issued2019-12-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/10985-
dc.description.abstractRNA-Seq was performed on liver and head kidney in four 'growth response groups'injected with polyinosinic-polycytidylic acid (Poly I:C; viral mimic), peptidoglycan (PGN;bacterial mimic) or PBS (control). These groups were: 1) 'W': wild-type, 2) 'TF': growth hormone (GH) transgenic salmon with ~3-fold higher growth-rate than W, 3) 'TR': GH transgenic fish ration restricted to possess a growth-rate equal to W, and 4) 'D': domesticated non-transgenic fish showing growth-rate intermediate to W and TF. D and TF showed a higher similarity in transcriptomic response compared to W and TR. Several immune genes showed constitutive expression differences among growth response groups, including perforin 1 and C-C motif chemokine 19-like. Among the affected immune pathways, most were up-regulated by Poly I:C and PGN. In response to PGN, the c-type lectin receptor signalling pathway responded uniquely in TF and TR. In response to stimulation with both immune mimics, TR responded more strongly than other groups. Further, group-specific pathway responses to PGN stimulation included NOD-like receptor signalling in W and platelet activation in TR. TF consistently showed the most attenuated immune response relative to W, and more DEGs were apparent in TR than TF and D relative to W, suggesting that a non-satiating ration coupled with elevated circulating GH levels may cause TR to possess enhanced immune capabilities. Alternatively, TF and D salmon are prevented from acquiring the same level of immune response as TR due to direction of energy to high overall somatic growth.en_US
dc.languageEnglishen_US
dc.language.isoenen_US
dc.subjectBiotechnology & Applied Microbiologyen_US
dc.subjectGenetics & Heredityen_US
dc.subject.classification해당사항없음en_US
dc.titleEffect of growth rate on transcriptomic responses to immune stimulation in wild-type, domesticated, and GH-transgenic coho salmonen_US
dc.title.alternative야생, 육종 및 유전자변형 연어의 성장률에 따른 전사체에 미치는 면역반응의 차이en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationKim, Jin-Hyoung, et al. 2019. "Effect of growth rate on transcriptomic responses to immune stimulation in wild-type, domesticated, and GH-transgenic coho salmon". <em>BMC GENOMICS</em>, 20(1024): 1-16.-
dc.citation.titleBMC GENOMICSen_US
dc.citation.volume20en_US
dc.citation.number1024en_US
dc.identifier.doi10.1186/s12864-019-6408-4-
dc.citation.startPage1en_US
dc.citation.endPage16en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2017:24.845en_US
dc.subject.keywordGrowthen_US
dc.subject.keywordPGNen_US
dc.subject.keywordPoly Ien_US
dc.subject.keywordcoho salmonen_US
dc.subject.keywordgrowth hormoneen_US
dc.subject.keywordimmunityen_US
dc.subject.keywordpleiotropyen_US
dc.subject.keywordselective breedingen_US
dc.subject.keywordtranscriptomicsen_US
dc.subject.keywordtransgenesisen_US
dc.subject.keywordcen_US
dc.identifier.localId2019-0330-
dc.identifier.scopusid2-s2.0-85077279747-
dc.identifier.wosid000504727300004-
Appears in Collections  
2019-2019, Polar Genomics 101 Project: Genome analysis of polar organisms and establishment of application platform (19-19) / Kim, Jin-Hyoung (PE19080)
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