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Enzymatic synthesis of anabolic steroids glycosides by glucosyltransferase from Terribacillus sp. PAMC 23288

Cited 1 time in wos
Cited 1 time in scopus

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dc.contributor.authorYu, Eun-Ji-
dc.contributor.authorYamaguchi, Tokutaro-
dc.contributor.authorLee, Joo-Ho-
dc.contributor.authorLim, A-Rang-
dc.contributor.authorLee, Jun Hyuck-
dc.contributor.authorPark, Hyun-
dc.contributor.authorOh, Tae-Jin-
dc.date.accessioned2021-05-20T08:12:20Z-
dc.date.available2021-05-20T08:12:20Z-
dc.date.issued2020-04-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/12092-
dc.description.abstractTo date, the use of steroid drugs has been steadily thanks to its effects, but due to severe side effects, studies on the derivative activity of steroids are being conducted. Nandrolone, a breast cancer drug, cortisone and prednisone which reduce inflammation, pain, and edema used in this study are not known as sugar derivatives. O-glucose was successfully linked using UDP-glucosyltransferase (UGT-1), and bioactivity was tested in vitro. NMR analysis found that those products produced by the nandrolone and testosterone were 17β-nandrolone β-D-glucose and 17β-testosterone β-D-glucose, respectively. In addition, testosterone derivatives in rotenone-treated PC12 cells showed higher cell viability and no cytotoxicity compared to control. In the presence of H2O2 in SH-SY5Y cells, nandrolone derivatives showed cell viability and attenuated cytotoxicity. Both derivatives also increased the renal protective effect and cellular ATP.en_US
dc.languageEnglishen_US
dc.language.isoen_USen_US
dc.subjectBiotechnology & Applied Microbiologyen_US
dc.subjectMicrobiologyen_US
dc.subject.classificationDasan Stationen_US
dc.titleEnzymatic synthesis of anabolic steroids glycosides by glucosyltransferase from Terribacillus sp. PAMC 23288en_US
dc.title.alternative북극 토양 미생물 (Terribacillus sp. PAMC 23288) 유래 glucosyltransferase 효소를 이용한 스테로이드 기질의 효소적 당화 반응 연구en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationYu, Eun-Ji, et al. 2020. "Enzymatic synthesis of anabolic steroids glycosides by glucosyltransferase from Terribacillus sp. PAMC 23288". <em>JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY</em>, 30(4): 604-614.-
dc.citation.titleJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGYen_US
dc.citation.volume30en_US
dc.citation.number4en_US
dc.identifier.doi10.4014/jmb.1911.11057-
dc.citation.startPage604en_US
dc.citation.endPage614en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2018:64.815en_US
dc.subject.keywordTestosteroneen_US
dc.subject.keywordnandroloneen_US
dc.subject.keywordglucosylationen_US
dc.subject.keywordneuroprotective activityen_US
dc.subject.keywordrotenone-induced apoptosisen_US
dc.subject.keywordsteroiden_US
dc.identifier.localId2020-0003-
dc.identifier.scopusid2-s2.0-85084167140-
dc.identifier.wosid000530070400016-
Appears in Collections  
2019-2019, Development of potential candidates as antibiotics based on polar genetic resources (19-19) / Lee, Jun Hyuck (PE19210)
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