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Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata

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dc.contributor.authorLee, Seulah-
dc.contributor.authorJeong, Se Yun-
dc.contributor.authorNGUYEN, Dieu Linh-
dc.contributor.authorSo, Jae Eun-
dc.contributor.authorKim, Ki Hyun-
dc.contributor.authorKim, Ji Hee-
dc.contributor.authorHan, Se Jong-
dc.contributor.authorSuh, Sung-Suk-
dc.contributor.authorLee, Jun Hyuck-
dc.contributor.authorYoun, Ui Joung-
dc.date.accessioned2022-04-13T04:48:00Z-
dc.date.available2022-04-13T04:48:00Z-
dc.date.issued2022-02-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/13301-
dc.description.abstractStereocalpin B, a new cyclic depsipeptide (1), and a new dibenzofuran derivative (3), were isolated from the Antarctic lichen, Ramalina terebrata (Ramalinaceae), along with a known cyclic depsipeptide (2). The structures of new compounds were characterized by comprehensive spectrometric analyses; high-resolution fast atom bombardment mass spectrometry (HR-FABMS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Stereocalpin B (1) existed in a rotameric equilibrium, which was confirmed using nuclear Overhauser effect spectroscopy (NOESY)/exchange spectroscopy (EXSY) spectrum. Absolute configurations of the amino acid units in 1 were assigned using the advanced Marfey's method and subsequent NOESY analysis of the 5-hydroxy-2,4-dimethyl-3-oxo-decanoic acid residue confirmed the complete stereochemistry of 1. Compounds 1-3 exhibited moderate antimicrobial activities against E. coli, with the IC50 values ranging from 18-30 mu g/mL. Compound 2 exhibited cell growth inhibition against HCT116 cell lines, with the IC50 value of 20 +/- 1.20 mu M, and compounds 1 and 2 also showed potent anti-inflammatory activities against lipopolysaccharide (LPS)-induced RAW264.7 macrophages with the IC50 values ranging from 5-7 mu M.en_US
dc.formatapplication/pdf-
dc.languageEnglishen_US
dc.subjectBiochemistry & Molecular Biology-
dc.subject.classificationKing Sejong Stationen_US
dc.titleStereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrataen_US
dc.title.alternative남극 지의류 Ramalina terebrata로부터 분리된 신규 cyclic depsipeptide, Stereocalpin Ben_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationLee, Seulah, et al. 2022. "Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata". <em>METABOLITES</em>, 12(2): 141-150.-
dc.citation.titleMETABOLITESen_US
dc.citation.volume12en_US
dc.citation.number2en_US
dc.identifier.doi10.3390/metabo12020141-
dc.citation.startPage141en_US
dc.citation.endPage150en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2020:31.864en_US
dc.subject.keywordRamalina terebrataen_US
dc.subject.keyworddibenzofuranen_US
dc.subject.keywordcyclic depsipeptidesen_US
dc.subject.keywordantimicrobialen_US
dc.subject.keywordcytotoxicityen_US
dc.subject.keywordanti-inflammationen_US
dc.identifier.localId2022-0019-
dc.identifier.scopusid2-s2.0-85124142085-
dc.identifier.wosid000775924000001-
Appears in Collections  
2021-2021, Development of potential candidates as antibiotics based on polar genetic resources (21-21) / Lee, Jun Hyuck (PM21030)
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