Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris
- Title
- Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris
- Other Titles
- 남극 지의류인 Himantormia lugubris에서 분리된 생리활성을 가진 이차대사산물
- Keywords
- Antimicrobial; Cytotoxicity; Depsidone; Himantormia lugubris; Lichen
- Issue Date
- 2022
- Citation
- Koo, Man Hyung, et al. 2022. "Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris". CHEMISTRY & BIODIVERSITY, 19(10): 1-7.
- Abstract
- Two new depsidones, himantormiones A and B (1 and 2) were isolated from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), together with seven known compounds (3-9). The structures of the new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR-MS. The isolated compounds were evaluated for their antimicrobial and cytotoxic activities, where himantormione B (2) exhibited an inhibitory effect against Staphylococcus aureus with the IC50 value of 7.01 ± 0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC50 value of 1.11 ± 0.85 μM, where that of the positive control, 5-fluouracil, was 9.4 ± 1.90 μM.
- Type
- Article
- Station
- King Sejong Station
- Indexed
- SCIE
- Appears in Collections
- 2022-2022, Development of potential antibiotic compounds using polar organism resources (22-22) / Lee, Jun Hyuck (PM22030)
- Files in This Item
- There are no files associated with this item.
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