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Two new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretion

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dc.contributor.authorKwon, Haeun-
dc.contributor.authorAnn, Hee Woon-
dc.contributor.authorLee, Jin Su-
dc.contributor.authorKwon, Jaeyoung-
dc.contributor.authorPark, Keunwan-
dc.contributor.authorGuo, Yuanqiang-
dc.contributor.authorHwang, Bang Yeon-
dc.contributor.authorJae-Jin Kim-
dc.contributor.authorYim, Joung Han-
dc.contributor.authorKim, Il-Chan-
dc.contributor.authorJang, Dae Sik-
dc.contributor.authorLee, Sullim-
dc.contributor.authorLee, Dongho-
dc.date.accessioned2026-02-10T03:43:07Z-
dc.date.available2026-02-10T03:43:07Z-
dc.date.issued2024-11-
dc.identifier.urihttps://repository.kopri.re.kr/handle/201206/16582-
dc.description.abstractA new cytosporin derivative (1) and a new phenolic compound (2), together with cytosporin D (3), were isolated from an EtOAc extract of Apiospora xenocordella culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structures of the new compounds were determined by using MS and NMR spectroscopic techniques, and the absolute configurations were established by the modified Mosher’s method and quantum chemical calculation of electronic circular dichroism. UV radiation activates pro-inflammatory cytokines, such as TNF-α, a major contributor to skin aging through ROS generation and MMP-1 secretion. Cytosporin D (3) exhibited the inhibition of TNF-α-induced ROS and MMP-1. UV radiation activates pro-inflammatory cytokines including TNF-α which is a major contributor to skin aging through reactive oxygen species (ROS) generation and matrix metalloproteinase-1 (MMP-1) secretion. Cytosporin D (3) exhibited moderate inhibition against TNF-α-induced ROS and MMP-1. This compound docked computationally into the active site of MMP-1 (?? 5.9 kcal/mol). Compound 1, though not tested due to limited quantity, showed a docking simulation result (?? 6.0 kcal/mol) similar to cytosporin D (3), indicating potential activity.en_US
dc.languageEnglishen_US
dc.subject.classification기타()en_US
dc.titleTwo new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretionen_US
dc.title.alternativeApiospora xenocordella 배양액에서 분리된 두 가지 새로운 화합물과 TNF-α 유도 ROS 생성 및 MMP-1 분비에 대한 이들의 억제 효과en_US
dc.typeArticleen_US
dc.identifier.bibliographicCitationKwon, Haeun, et al. 2024. "Two new compounds from Apiospora xenocordella culture medium and their inhibitory effects on TNF-α-induced ROS generation and MMP-1 secretion". <em>Phytochemistry Letters</em>, 65(0): 38-43.-
dc.citation.titlePhytochemistry Lettersen_US
dc.citation.volume65en_US
dc.citation.number0en_US
dc.identifier.doihttps://doi.org/10.1016/j.phytol.2024.11.005-
dc.citation.startPage38en_US
dc.citation.endPage43en_US
dc.description.articleClassificationSCIE-
dc.description.jcrRateJCR 2023:63.019en_US
dc.subject.keywordApiospinen_US
dc.subject.keywordApiospora xenocordellaen_US
dc.subject.keywordCytosporin Zen_US
dc.subject.keywordMMP-1 secretionen_US
dc.subject.keywordMolecular Networkingen_US
dc.subject.keywordROS generationen_US
dc.identifier.localId2025-0386-
Appears in Collections  
2024-2024, 포스트 극지유전체 프로젝트: 극지 유용유전자 발굴을 위한 기능유전체 연구 (24-24) / 김진형 (PE24160)
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