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Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters

Cited 5 time in wos
Cited 8 time in scopus
Title
Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters
Authors
Kim, Jung-Ho
Bhatia, Shashi Kant
Yoo, Dongwon
Seo, Hyung Min
Yi, Da-Hye
Kim, Hyun Joong
Lee, Ju Hee
Choi, Kwon-Young
Kim, Kwang Jin
Lee, Yoo Kyung
Yang, Yung-Hun
Subject
Biochemistry & Molecular BiologyBiotechnology & Applied Microbiology
Keywords
6-O-cinnamoyl-sorbitolCandida antarcticaEnzymatic synthesisLipaseSorbitol
Issue Date
2014
Citation
Kim, Jung-Ho, et al. 2014. "Lipase-Catalyzed Production of 6-O-cinnamoyl-sorbitol from D-sorbitol and Cinnamic Acid Esters". Applied Biochemistry and Biotechnology, 176: 244-252.
Abstract
To overcome the poor properties of solubility and stability of cinnamic acid, cinnamate derivatives with sugar alcohols were produced using the immobilized Candida antarctica lipase with vinyl cinnamate and D-sorbitol as substrate at 45 °C. Immobilized C. antarctica lipase was found to synthesize 6-O-cinnamoyl-sorbitol and confirmed by HPLC and 1H-NMR and had a preference for vinyl cinnamate over other esters such as allyl-, ethyl-, and isobutyl cinnamate as co-substrate with D-sorbitol. Contrary to D-sorbitol, vinyl cinnamate, and cinnamic acid, the final product 6-O-cinnamoyl-sorbitol was found to have radical scavenging activity. This would be the first report on the biosynthesis of 6-Ocinnamoyl- sorbitol with immobilized enzyme from C. antarctica.
DOI
http://dx.doi.org/10.1007/s12010-015-1570-x
Type
Article
Appears in Collections  
2014-2016, Environmental Change Studies Based on The Arctic Dasan Station: in terms of Geology, Atmospheric Science, and Ecology (14-16) / Lee; Yookyung (PE14030; PE15030; PE16030)
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