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Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins

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Cited 10 time in scopus
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Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins
Lee, Jun Hyuck
Park, HaJeung
Park, Yong Ho
Biochemistry & Molecular Biology; Chemistry
Actin; Bacillary dysentery; Bacterial proteins; Invasin; Shigella
Issue Date
Lee, Jun Hyuck, Park, HaJeung, Park, Yong Ho. 2014. "Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins". International Journal of Molecular Sciences,, 15: 18253-18266.
Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.
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